World Journal of Surgery

, Volume 28, Issue 12, pp 1187–1198

Current Strategies for Surgical Management and Adjuvant Treatment of Childhood Papillary Thyroid Carcinoma

  • Geoffrey B. Thompson
  • Ian D. Hay
Article

Abstract

Childhood papillary thyroid carcinoma is associated with more locally aggressive and more frequent distant disease than its adult counterpart. Recurrence rates tend to be higher in children, but cause-specific mortality remains low. Optimal initial treatment of childhood papillary thyroid carcinoma should include total or near-total thyroidectomy and central compartment node clearance. Modified neck dissections should be performed for biopsy-proven lateral neck disease. Every effort should be made to maintain parathyroid and laryngeal nerve function. Radical neck dissections are to be avoided. Radioiodine remnant ablation (RRA), appropriate thyroid hormone suppressive therapy (THST), and judicious use of therapeutic doses of 131I are applied to achieve a disease-free status, which is most often confirmed by negative neck ultrasonography, negative whole-body scan (either withdrawal or recombinant human thyroid-stimulating hormone-stimulated), and extremely low levels of serum thyroglobulin. Appropriate utilization of 131I, THST, repeat surgery, external beam radiotherapy, and rarely chemotherapy may provide long-term palliation and some cures in patients with recurrent/persistent disease. Follow-up should be lifelong, and the care of children after age 17 should subsequently be transferred to adult-care endocrinologists with expertise in managing thyroid neoplasia. Optimal surgical management can be achieved if adequate operations are routinely carried out by “high-volume” thyroid surgeons with expertise in the care of children. Nowhere is a multidisciplinary approach (endocrinologists, surgeons, nuclear medicine physicians, pediatricians, pathologists, oncologists) more critical than in the long-term management of papillary thyroid carcinoma that presents during childhood.

References

  1. 1.
    Hung, W, Sarlis, NJ 2002Current controversies in the management of pediatric patients with well-differentiated nonmedullary thyroid cancer: a reviewThyroid12683702CrossRefPubMedGoogle Scholar
  2. 2.
    Bernstein L, Gurney JG. Carcinomas and Other Malignant Epithelial Neoplasms. ICCC XI. Pediatric Monograph, NCI Seer. Available at www.seer.cancer.gov/Publications/childhood/carcinomas.pdfGoogle Scholar
  3. 3.
    Harness JK. Childhood thyroid carcinoma. In Clark OH, Duh Q-Y, editors, Textbook of Endocrine Surgery, Philadelphia, Saunders, 1997;75–81Google Scholar
  4. 4.
    Young, JL, Percy, CL, Asire, AJ,  et al. 1981Cancer incidence and mortality in the United States, 1973-1977Natl. Cancer Inst. Monogr.571Google Scholar
  5. 5.
    Harach, HR, Williams, ED 1995Childhood thyroid cancer in England and WalesBr. J. Cancer72777783PubMedGoogle Scholar
  6. 6.
    LiVolsi VA1992Papillary neoplasms of the thyroid: pathologic and prognostic featuresAm. J. Clin. Pathol.97426Google Scholar
  7. 7.
    Stoffer, SS, Dyke, DL, VandenBach, J,  et al. 1986Familial papillary carcinoma of the thyroidAm. J. Med. Genet.25775PubMedGoogle Scholar
  8. 8.
    Duffy, BJ, Fitzgerald, PJ 1950Cancer of the thyroid in children: a report of 28 casesJ. Clin. Endocrinol. Metab.101296PubMedGoogle Scholar
  9. 9.
    Winship, T, Rosvoll, R 1970Thyroid carcinoma in children: final report of a 20-year studyClin. Proc. Child. Hosp. D.C.2611Google Scholar
  10. 10.
    Harness, JK, Thompson, NW, McLeod, MK,  et al. 1992Differentiated thyroid carcinoma in children and adolescentsWorld J. Surg.16547554PubMedGoogle Scholar
  11. 11.
    Ceccarelli, C, Pacini, F, Lippi, F,  et al. 1988Thyroid cancer in children and adolescentsSurgery10411431148PubMedGoogle Scholar
  12. 12.
    Goepfert, H, Dichtel, WJ, Samaan, NA 1984Thyroid cancer in children and teenagersArch. Otolaryngol.11072PubMedGoogle Scholar
  13. 13.
    Buckwalter, JA, Gurll, NJ, Thomas, CG,Jr 1981Cancer of the thyroid in youthWorld J. Surg.515PubMedGoogle Scholar
  14. 14.
    Schlumberger, M, Vathaire, F, Travagli, JP,  et al. 1987Differentiated thyroid carcinoma in childhood: long-term follow-up of 72 patientsJ. Clin. Endocrinol. Metab.6510881094PubMedGoogle Scholar
  15. 15.
    Conard RA. Late radiation effects in Marshall Islanders exposed to fallout 28 years ago. In Boice JD Jr, Fraumeni JF Jr, editors, Radiation Carcinogenesis: Epidemiology and Biological Significance, New York, Raven, 1984;57–71Google Scholar
  16. 16.
    Akiba S, Lubin J, Ezaki H, et al. Thyroid Cancer Incidence among Atomic Bomb Survivors in Hiroshima and Nagasaki, 1958-1979b (Technical Report TR 5-91). Hiroshima, Radiation Effects Research Foundation, 1991Google Scholar
  17. 17.
    Viswanathan K, Gierlowski TC, Schneider AB. Children thyroid cancer: characteristics and long-term outcome in children irradiated for benign conditions of the head and neck. Arch. Pediatr. Adolesc. Med. 1994;1948:260Google Scholar
  18. 18.
    Oleynic VA, Cheban AK. Thyroid cancer in children of Ukraine from 1981 to 1992. In Robbins J, editor, Treatment of Thyroid Cancer in Childhood, Bethesda, National Institutes of Health, 1994;45-4919. Astakhova LN, Vorontsova TV, Arozd VM. Thyroid nodule pathology in children of the Republic of Belarus following the Chernobyl accident. In Robbins J, editor, Treatment of Thyroid Cancer in Childhood, Bethesda, National Institutes of Health, 1994;35-39Google Scholar
  19. 19.
    Storm, HH, Plesko, I 2001Survival of children with thyroid cancer in Europe 1978-1989Eur. J. Cancer37775779CrossRefPubMedGoogle Scholar
  20. 20.
    Verger, P, Catelinois, O, Tirmarche, M,  et al. 2003Thyroid cancers in France and the Chernobyl accident: risk assessment and recommendations for improving epidemiological knowledgeHealth Phys.85323329CrossRefPubMedGoogle Scholar
  21. 21.
    Jacob, P, Goulko, G, Heidenreich, WF,  et al. 1998Thyroid cancer risk to children calculatedNature3923132CrossRefPubMedGoogle Scholar
  22. 22.
    Rybakov, SJ, Komissarenko, IV, Tronko, ND,  et al. 2000Thyroid cancer in children of Ukraine after the Chernobyl accidentWorld J. Surg.2414461449CrossRefPubMedGoogle Scholar
  23. 23.
    Rahu, M 2003Health effects of the Chernobyl accident: fears, rumours, and the truthEur. J. Cancer39295299CrossRefPubMedGoogle Scholar
  24. 24.
    Moysich, KB, Menezes, RJ, Michalek, AM 2002Chernobyl-related ionising radiation exposure and cancer risk: an epidemiological reviewLancet Oncol.3269279CrossRefPubMedGoogle Scholar
  25. 25.
    Jackson, RJ, DeLozier, DM, Gerasimov, G,  et al. 2002Chernobyl and iodine deficiency in the Russian Federation: an environmental disaster leading to a public health opportunityJ. Public Health Policy23453470PubMedGoogle Scholar
  26. 26.
    Rabes, HM, Demidchik, EP, Sidorow, JD,  et al. 2000Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-Chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implicationsClin. Cancer Res.610931103PubMedGoogle Scholar
  27. 27.
    Elisei, R, Romei, C, Vorontsova, T,  et al. 2001RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adultsJ. Clin. Endocrinol. Metab.8632113216Google Scholar
  28. 28.
    Fenton, CL, Lukes, Y, Nicholson, D,  et al. 2000The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adultsJ. Clin. Endocrinol. Metab.8511701175Google Scholar
  29. 29.
    Alsanea, O, Wata, N, Ain, K,  et al. 2000Is familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter seriesSurgery12810431050CrossRefPubMedGoogle Scholar
  30. 30.
    Canzian, F, Amati, P, Harach, HR,  et al. 1998A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2Am. J. Hum. Genet.6317431748CrossRefPubMedGoogle Scholar
  31. 31.
    Malchoff, CD, Sarfarazi, M, Tendler, B,  et al. 2000Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndromeJ. Clin. Endocrinol. Metab.8517581764Google Scholar
  32. 32.
    Kirkland, RT, Kirkland, JL, Rosenberg, HS 1973Solitary thyroid nodules in 30 children and report of a child with a thyroid abscessPediatrics5185PubMedGoogle Scholar
  33. 33.
    Harness, JK, Thompson, NW, Nishiyama, RH 1971Childhood thyroid carcinomaArch. Surg.102278PubMedGoogle Scholar
  34. 34.
    Fowler, CL, Pokorny, WJ, Harberg, FJ 1989Thyroid nodules in children: current profile of changing diseaseSouth. Med. J.821472PubMedGoogle Scholar
  35. 35.
    Corrias, A, Einaudi, S, Chiorboli, E,  et al. 2001Accuracy of fine-needle aspiration biopsy of thyroid nodules in detecting malignancy in childhood: comparison with conventional clinical, laboratory, and imaging approachesJ. Clin. Endocrinol. Metab.8646444648CrossRefPubMedGoogle Scholar
  36. 36.
    Zimmerman, D, Hay, ID, Gough, IR,  et al. 1988Papillary thyroid carcinoma in children and adults: long-term follow-up of 1039 patients conservatively treated at one institution during three decadesSurgery10411571166PubMedGoogle Scholar
  37. 37.
    LaQuaglia, MP, Corbally, MT, Heller, G,  et al. 1988Recurrence and morbidity in differentiated thyroid carcinoma in childrenSurgery10411491156PubMedGoogle Scholar
  38. 38.
    Suarez, HG 1998Genetic alterations in human epithelial thyroid tumoursClin. Endocrinol. (Oxf.)48531546CrossRefGoogle Scholar
  39. 39.
    Farid, NR, Zou, M, Shi, Y 1995Genetics of follicular thyroid cancerEndocrinol. Metab. Clin. North Am.24865883PubMedGoogle Scholar
  40. 40.
    Kroll, TG, Sarraf, P, Pecciarini, L,  et al. 2000PAX8-PPARγ1 fusion oncogene in human thyroid carcinomaScience28913571360CrossRefPubMedGoogle Scholar
  41. 41.
    Beahrs OH, Henson DE, Hutter RVP, et al. Manual for Staging of Cancer, Philadelphia, Lippincott, 1992Google Scholar
  42. 42.
    Fleming ID, Cooper JS, Henson DE, et al, editors. AJCC Cancer Staging Manual, Philadelphia, Lippincott-Raven, 1997Google Scholar
  43. 43.
    Hay, ID, McConahey, WM, Goellner, JR 2002Managing patients with papillary thyroid carcinoma: insights gained from the Mayo Clinic’s experience of treating 2,512 consecutive patients during 1940 through 2000Trans. Am. Clin. Climatol. Assoc.113241260PubMedGoogle Scholar
  44. 44.
    Hay, ID, Bergstralh, EJ, Goellner, JR,  et al. 1993Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1,779 patients surgically treated at one institution during 1940 through 1989Surgery11410501058PubMedGoogle Scholar
  45. 45.
    Hay, ID, Thompson, GB, Grant, CS,  et al. 2002Papillary thyroid carcinoma managed at the Mayo Clinic during six decades (1940-1999): temporal trends in initial therapy and long-term outcome in 2444 consecutively treated patientsWorld J. Surg.26879885CrossRefPubMedGoogle Scholar
  46. 46.
    Hamburger, JL 1994Diagnosis of thyroid nodules by fine needle biopsy: use and abuseJ. Clin. Endocrinol. Metab.79335339CrossRefPubMedGoogle Scholar
  47. 47.
    Gharib, H 1997Changing concepts in the diagnosis and management of thyroid nodulesEndocrinol. Metab. Clin. North Am.2677777800Google Scholar
  48. 48.
    Nelson, RL, Wahaner, HW, Gorman, CA 1978Rectilinear thyroid scanning as a predictor of malignancyAnn. Intern. Med.884144PubMedGoogle Scholar
  49. 49.
    Hughes, FC, Bauden, M, Laccourreye, H 1989Le nodule thyroidien: une étude rétrospective de 200 observationsAnn. Otolaryngol. Chir. Cervicofac.1067781PubMedGoogle Scholar
  50. 50.
    Paphavasit, A, Thompson, GB, Hay, ID,  et al. 1997Follicular and Hürthle cell thyroid neoplasms: is frozen section evaluation worthwhile?Arch. Surg.132674679Google Scholar
  51. 51.
    Haveman, JW, Tol, KM, Rouwe, CW,  et al. 2003Surgical experience in children with differentiated thyroid carcinomaAnn. Surg. Oncol.101520CrossRefPubMedGoogle Scholar
  52. 52.
    Kowalski, LP, Filho, JG, Pinto, CAL,  et al. 2003Long-term survival rates in young patients with thyroid carcinomaArch. Otolaryngol. Head Neck Surg.129746749CrossRefPubMedGoogle Scholar
  53. 53.
    Giuffrida, D, Scollo, C, Pellegriti, G,  et al. 2002Differentiated thyroid cancer in children and adolescentsJ. Endocrinol. Invest.251824PubMedGoogle Scholar
  54. 54.
    Arici, C, Erdogan, O, Altunbas, H,  et al. 2002Differentiated thyroid carcinoma in children and adolescents: clinical characteristics, treatment and outcome of 15 patientsHorm. Res.57153156CrossRefPubMedGoogle Scholar
  55. 55.
    Grigsby, PW, Gal-or, A, Michalski, JM,  et al. 2002Childhood and adolescent thyroid carcinomaCancer95724729CrossRefPubMedGoogle Scholar
  56. 56.
    Arush, MWB, Stein, ME, Nahum, MP,  et al. 2000Pediatric thyroid carcinoma: 22 years of experience at the Northern Israel Oncology Center (1973-1995)Pediatr. Hematol. Oncol.17875892Google Scholar
  57. 57.
    Brink, JS, Heerden, JA, McIver, B,  et al. 2000Papillary thyroid cancer with pulmonary metastases in children: long-term prognosisSurgery128881887CrossRefPubMedGoogle Scholar
  58. 58.
    Jarzab, B, Junak, DH, Wloch, J,  et al. 2000Multivariate analysis of prognostic factors for differentiated thyroid carcinoma in childrenEur. J. Nucl. Med.27833841CrossRefPubMedGoogle Scholar
  59. 59.
    Landau, D, Vini, L, Ahern, R,  et al. 2000Thyroid cancer in children: the Royal Marsden Hospital experienceEur. J. Cancer36214220CrossRefPubMedGoogle Scholar
  60. 60.
    LaQuaglia, MP, Black, T, Holcomb, GW,III,  et al. 2000Differentiated thyroid cancer: clinical characteristics, treatment, and outcome in patients under 21 years of age who present with distant metastases: a report from the Surgical Discipline Committee of the Children’s Cancer GroupJ. Pediatr. Surg.35955960CrossRefPubMedGoogle Scholar
  61. 61.
    Dinauer, CAW, Tuttle, RM, Robie, DK,  et al. 1997Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adultsClin. Endocrinol. (Oxf.)49619628CrossRefGoogle Scholar
  62. 62.
    Newman, KD, Black, T, Heller, G,  et al. 1998Differentiated thyroid cancer: determinants of disease progression in patients < 21 years of age at diagnosis: a report from the Surgical Discipline Committee of the Children’s Cancer GroupAnn. Surg.227533541CrossRefPubMedGoogle Scholar
  63. 63.
    Segald, K, Shvero, J, Stern, Y,  et al. 1998Surgery of thyroid cancer in children and adolescentsHead Neck20293297CrossRefPubMedGoogle Scholar
  64. 64.
    Vassilopoulou-Sellin, R, Goepfert, H, Raney, B,  et al. 1998Differentiated thyroid cancer in children and adolescents: clinical outcome and mortality after long-term follow-upHead Neck20549555CrossRefPubMedGoogle Scholar
  65. 65.
    Vassilopoulou-Sellin, R, Schultz, PN, Haynie, TP 1996Clinical outcome of patients with papillary thyroid carcinoma who have recurrence after initial radioactive iodine therapyCancer78493501CrossRefPubMedGoogle Scholar
  66. 66.
    Singer, P, Cooper, DS, Daniels, GH 1996Treatment guidelines for the management of thyroid carcinomaArch. Intern. Med.15621652172CrossRefPubMedGoogle Scholar
  67. 67.
    Hay, ID, Feld, S, Garcia, M 1997AACE clinical practice guidelines for the management of thyroid carcinomaEndocr. Pract.36071Google Scholar
  68. 68.
    Shaha, AR, Byers, RM, Terz, JJ 1997Thyroid cancer surgical practice guidelines: scope and format of guidelinesOncology1112281234PubMedGoogle Scholar
  69. 69.
    Thyroid Carcinoma Task Force2001AACE/AAES medical/surgical guidelines for clinical practice: management of thyroid carcinomaEndocr. Pract.7202221Google Scholar
  70. 70.
    Mazzaferri, EL 1999NCCN thyroid carcinoma practice guidelinesOncology13391416Google Scholar
  71. 71.
    Scheumann, GFW, Seeliger, H, Musholt, TJ,  et al. 1996Completion thyroidectomy in 131 patients with differentiated thyroid carcinomaActa Chir.162677684Google Scholar
  72. 72.
    McGregor, LM, Rosoff, PM 2001Follicle-derived thyroid cancer in young people: the Duke experiencePediatr. Hematol. Oncol.1889100CrossRefPubMedGoogle Scholar
  73. 73.
    Skinner, MA 2001Cancer of the thyroid gland in infants and childrenSemin. Pediatr. Surg.10119126CrossRefPubMedGoogle Scholar
  74. 74.
    Hay, ID, Grant, CS, Bergstralh, EJ,  et al. 1998Unilateral total lobectomy: is it sufficient surgical treatment for patients with AMES low-risk papillary thyroid carcinoma?Surgery124958966CrossRefPubMedGoogle Scholar
  75. 75.
    Hay, ID, Grant, CS, Heerden, JA,  et al. 1992Papillary thyroid microcarcinoma: a study of 535 cases observed in a 50-year periodSurgery11211391147PubMedGoogle Scholar
  76. 76.
    Hay, ID 1990Papillary thyroid carcinomaEndocrinol. Metab. Clin. North Am.19545576PubMedGoogle Scholar
  77. 77.
    McConahey, WM, Hay, ID, Woolner, LB,  et al. 1986Papillary thyroid cancer treated at the Mayo Clinic, 1946 through 1970: initial manifestations, pathologic findings, therapy and outcomeMayo Clin. Proc.61978996PubMedGoogle Scholar
  78. 78.
    Jong, SA, Demeter, JG, Lawrence, AM,  et al. 1992Necessity and safety of completion thyroidectomy for differentiated thyroid carcinomaSurgery112734739PubMedGoogle Scholar
  79. 79.
    Beierwaltes, WH 1978The treatment of thyroid carcinoma with radioactive iodineSemin. Nucl. Med.87994PubMedGoogle Scholar
  80. 80.
    Paryani, SB, Chobe, RJ, Scott, W,  et al. 1996Management of thyroid carcinoma with radioactive 131IInt. J. Radiat. Oncol. Biol. Phys.36S83S86CrossRefGoogle Scholar
  81. 81.
    Goolden, AWG 1988The use of radioactive iodine in thyroid carcinomaEur. J. Cancer Clin. Oncol.24339343CrossRefPubMedGoogle Scholar
  82. 82.
    Gorlin, JB, Sallen, SE 1990Thyroid cancer in childhoodEndocrinol. Metab. Clin. North Am.19649662PubMedGoogle Scholar
  83. 83.
    Desjardins, JG, Bass, J, Leboeuf, G,  et al. 1988A twenty-year experience with thyroid carcinoma in childrenJ. Pediatr. Surg.23709713PubMedGoogle Scholar
  84. 84.
    McClellan, DR, Francis, GL 1996Thyroid cancer in children, pregnant women, and patients with Graves’ diseaseEndocrinol. Metab. Clin. North Am.252748PubMedGoogle Scholar
  85. 85.
    Welch Dinauer, CA, Tuttle, RM, Robie, DK,  et al. 1998Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents, and young adultsClin. Endocrinol. (Oxf.)49619628CrossRefGoogle Scholar
  86. 86.
    Sykes, AJ, Gattamanen, HR 1997Carcinoma of the thyroid in children: a 25-year experienceMed. Pediatr. Oncol.29103107CrossRefPubMedGoogle Scholar
  87. 87.
    Fassina, AS, Rupolo, M, Pelizzo, MR,  et al. 1994Thyroid cancer in children and adolescentsTumori80257262PubMedGoogle Scholar
  88. 88.
    Danese, D, Gardini, A, Farsetti, A,  et al. 1997Thyroid carcinoma in children and adolescentsEur. J. Pediatr.156190194CrossRefPubMedGoogle Scholar
  89. 89.
    Dottorini, ME, Vignati, A, Mazzucchelli, L,  et al. 1997Differentiated thyroid carcinoma in children and adolescents: a 37-year experience in 85 patientsJ. Nucl. Med.38669675PubMedGoogle Scholar
  90. 90.
    Yeh, SD, Quaglia, MP 1997131I therapy for pediatric thyroid cancerSemin. Pediatr. Surg.6128133PubMedGoogle Scholar
  91. 91.
    Jeevanram, RK, Shah, DH, Sharma, SM,  et al. 1986Influence of initial large dose on subsequent uptake of therapeutic radioiodine in thyroid cancer patientsInt. J. Radiat. Appl. Instrum. B13277279Google Scholar
  92. 92.
    Park, HM, Perkins, OW, Edmondson, JW,  et al. 1994Influence of diagnostic radioiodine in the uptake of ablative dose iodine-131Thyroid44954PubMedGoogle Scholar
  93. 93.
    Muratet, JP, Daver, A, Minier, JF 1998Influence of scanning doses of iodine-131 on subsequent first ablative treatment outcome in patients operated on for differentiated thyroid carcinomaJ. Nucl. Med.3915461550PubMedGoogle Scholar
  94. 94.
    Reynolds, JC 1997Percent 131I uptake and post-therapy 131I scans: their role in the management of thyroid cancerThyroid7281284PubMedGoogle Scholar
  95. 95.
    Schlumberger, M, Arcangioli, O, Piekarski, JD,  et al. 1988Detection and treatment of lung metastases of differentiated thyroid carcinoma in patients with normal chest x-raysJ. Nucl. Med.2917901794PubMedGoogle Scholar
  96. 96.
    Diederich, S, Lenzen, H 2000Radiation exposure associated with imaging of the chest: comparison of different radiographic and computed tomography techniquesCancer8924572460CrossRefPubMedGoogle Scholar
  97. 97.
    Snyder WS, Ford MR, Warner GG, et al. “S,” Absorbed Dose per Unit Cumulated Activity for Selected Radionuclides and Organs, MIRD (Medical Internal Radiation Dose Committee) Pamphlet 11, Reston, VA, Society of Nuclear Medicine, 1975Google Scholar
  98. 98.
    Loevinger R, Berman M. A Revised Schema for Absorbed-dose Calculations for Biologically Distributed Radionuclides. MIRD (Medical Internal Radiation Dose Committee) Pamphlet 1—Revised, Reston, VA, Society of Nuclear Medicine, 1976Google Scholar
  99. 99.
    Mazzaferri, EL 1999An overview of the management of papillary and follicular thyroid carcinomaThyroid9421428PubMedGoogle Scholar
  100. 100.
    Doi, SAR, Woodhouse, NJY 2000Ablation of thyroid remnant and 131I dose in differentiated thyroid cancerClin. Endocrinol. (Oxf.)52765773CrossRefGoogle Scholar
  101. 101.
    Robbins, J, Merino, MJ, Boice, JD,  et al. 1991Thyroid cancer: a lethal endocrine neoplasmAnn. Intern. Med.115133147PubMedGoogle Scholar
  102. 102.
    Pineda, JD, Lee, T, Ain, K,  et al. 1995Iodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scanJ. Clin. Endocrinol. Metab.8014881492CrossRefPubMedGoogle Scholar
  103. 103.
    Robbins, J 1999Management of thyroglobulin-positive, body scan-negative thyroid cancer patients: evidence for utility of I-131 therapyJ. Endocrinol. Invest.22808810PubMedGoogle Scholar
  104. 104.
    Pacini, F, Agate, L, Elisei, R,  et al. 2001Outcome of differentiated thyroid cancer with detectable serum TG and negative diagnostic 131I whole body scan: comparison of patients treated with high 131I activities versus untreated patientsJ. Clin. Endocrinol. Metab.8640924097Google Scholar
  105. 105.
    Maxon, HR 1999Quantitative radioiodine therapy in the treatment of differentiated thyroid cancerQ. J. Nucl. Med.43313323PubMedGoogle Scholar
  106. 106.
    Benua, RS, Cicale, NR, Sonenberg, M 1962er al. The relation of radioiodine dosimetry to results and complications in the treatment of metastatic thyroid cancerAJR Am. J. Roentgenol.87171186Google Scholar
  107. 107.
    Nostrand, D, Neutze, J, Atkins, F 1986Side effects of “rational dose” iodine-131 therapy for metastatic well-differentiated thyroid carcinomaJ. Nucl. Med.2715191527PubMedGoogle Scholar
  108. 108.
    Beierwaltes, WH, Nishiyama, RH, Thompson, NW,  et al. 1982Survival time and “cure” in papillary and follicular thyroid carcinoma with distant metastases: statistics following University of Michigan therapyJ. Nucl. Med.25561568Google Scholar
  109. 109.
    Schlumberg, M, Mancusi, F, Baudin, E,  et al. 1997131I therapy for elevated thyroglobulin levelsThyroid7273276PubMedGoogle Scholar
  110. 110.
    Li, BL, Hu, J, Want, XF,  et al. 1990Prognostic significance of general immune competence in acute leukemiaMed. Oncol. Tumor Pharmacother.7233239PubMedGoogle Scholar
  111. 111.
    Doria, G, Biozzi, G, Mouton, D,  et al. 1997Genetic control of immune responsiveness, aging and tumor incidenceMech. Aging Dev.96113Google Scholar
  112. 112.
    Gupta, S, Patel, A, Folstad, A,  et al. 2001Infiltration of differentiated thyroid carcinoma by proliferating lymphocytes is associated with improved disease-free survival for children and young adultsJ. Clin. Endocrinol. Metab.8613461354Google Scholar
  113. 113.
    Modi, J, Patel, A, Terrell, R,  et al. 2003Papillary thyroid carcinomas from young adults and children contain a mixture of lymphocytesJ. Clin. Endocrinol. Metab.8844184425CrossRefPubMedGoogle Scholar
  114. 114.
    Mazzaferri, EL, Kloos, RT 2000Using recombinant human TSH in the management of well-differentiated thyroid cancer: current strategies and future directionThyroid10767778PubMedGoogle Scholar
  115. 115.
    Menzel, C, Grunwald, F, Schomburg, A,  et al. 1996High-dose” radioiodine therapy in advanced differentiated thyroid carcinomaJ. Nucl. Med.3714961503PubMedGoogle Scholar
  116. 116.
    Sisson, JC 1989Medical treatment of benign and malignant thyroid tumorsEndocrinol. Metab. Clin. North Am.18359387PubMedGoogle Scholar
  117. 117.
    Edmonds, CJ, Smith, T 1986The long-term hazards of the treatment of thyroid cancer with radioiodineBr. J. Radiol.594551Google Scholar
  118. 118.
    Schlumberger, M, Vathaire, F, Ceccarelli, C,  et al. 1996Exposure to radioactive iodine-131 for scintigraphy or therapy does not preclude pregnancy in thyroid cancer patientsJ. Nucl. Med.37606612PubMedGoogle Scholar
  119. 119.
    Winters, S, Berga, S 1997Gonadal dysfunction in patients with thyroid disordersEndocrinologist7167173Google Scholar
  120. 120.
    Wang, PW, Wang, ST, Liu, RT,  et al. 1999Levothyroxine suppression of thyroglobulin in patients with differentiated thyroid carcinomaJ. Clin. Endocrinol. Metab.8445494553CrossRefPubMedGoogle Scholar
  121. 121.
    Ringel, MD, Balducci-Silano, PL, Anderson, JS,  et al. 1999Quantitative reverse transcription-polymerase chain reaction of circulating thyroglobulin messenger ribonucleic acid for monitoring patients with thyroid carcinomaJ. Clin. Endocrinol. Metab.8440374042CrossRefPubMedGoogle Scholar
  122. 122.
    O’Connell, ME, Ahern, RP, Harmer, CL 1994Results of external beam radiotherapy in differentiated thyroid carcinoma: a retrospective study from the Royal Marsden HospitalEur. J. Cancer30A733739CrossRefPubMedGoogle Scholar
  123. 123.
    Mazzarotto, R, Cesaro, MG, Lora, O,  et al. 2000The role of external beam radiotherapy in the management of differentiated thyroid cancerBiomed. Pharmacother.54345349CrossRefPubMedGoogle Scholar
  124. 124.
    Brierley, JD, Tsang, RW 1999External-beam radiation therapy in the treatment of differentiated thyroid cancerSemin. Surg. Oncol.164249CrossRefPubMedGoogle Scholar
  125. 125.
    Shimaoka, K, Schoenffeld, DA, DeWys, WD,  et al. 1985A randomized trial of doxorubicin versus doxorubicin plus cisplatin in patients with advanced thyroid carcinomaCancer5621552160Google Scholar
  126. 126.
    Besi, P, Busnardo, B, Toso, S,  et al. 1991Combined chemotherapy with bleomycin, adriamycin, and platinum in advanced thyroid cancerJ. Endocrinol. Invest.14475480PubMedGoogle Scholar
  127. 127.
    Kim, JH, Leeper, RD 1983Treatment of anaplastic giant and spindle cell carcinoma of the thyroid gland with combination adriamycin and radiation therapy: a new approachCancer52954960PubMedGoogle Scholar
  128. 128.
    Ain, KB, Tofiq, S, Taylor, KD 1996Antineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivoJ. Clin. Endocriniol. Metab.8136503653CrossRefGoogle Scholar
  129. 129.
    Xu, G, Pan, J, Martin, C,  et al. 2001Angiogenesis inhibition in the in vivo antineoplastic effect of manumycin and paclitaxel against anaplastic thyroid carcinomaJ. Clin. Endocrinol. Metab.8617691777Google Scholar
  130. 130.
    Straight, AM, Patel, A, Fenton, C,  et al. 2002Thyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescentsJ. Endocrinol. Invest.25302308PubMedGoogle Scholar
  131. 131.
    Patel, A, Jhiang, S, Dogra, S,  et al. 2002Differentiated thyroid carcinoma that express sodium-iodide symporter have a lower risk of recurrence for children and adolescentsPediatr. Res.52737744CrossRefPubMedGoogle Scholar
  132. 132.
    Patel, A, Straight, AM, Mann, H,  et al. 2002Matrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma in children and adolescentsJ. Endocrinol. Invest.25403408PubMedGoogle Scholar
  133. 133.
    Ramirez, R, Hsu, D, Patel, A,  et al. 2000Over-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinomaClin. Endocrinol. (Oxf.)53635644CrossRefGoogle Scholar
  134. 134.
    Ramirez, R, Hsu, D, Patel, A,  et al. 2000Over-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinomaClin. Endocrinol. (Oxf.)53635644CrossRefGoogle Scholar
  135. 135.
    Shah, R, Banks, K, Patel, A,  et al. 2002Intense expression of the b7-2 antigen presentation coactivator is an unfavorable prognostic indicator for differentiated thyroid carcinoma of children and adolescentsJ. Clin. Endocrinol. Metab.8743914397Google Scholar

Copyright information

© Société Internationale de Chirurgie 2004

Authors and Affiliations

  • Geoffrey B. Thompson
    • 1
  • Ian D. Hay
    • 1
  1. 1.Department of Surgery Mayo Clinic and Mayo FoundationRochesterUSA
  2. 2.Division of Endocrinology and Internal MedicineMayo Clinic and Mayo FoundationRochesterUSA

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