World Journal of Surgery

, Volume 28, Issue 11, pp 1071–1074 | Cite as

Clinical Analysis of Thyroid Cancer in Adult Patients Exposed to Ionizing Radiation due to the Chernobyl Nuclear Accident: 5-Year Comparative Investigations Based on the Results of Surgical Treatment

  • Sergiy M. Cherenko
  • Oleksandr S. Larin
  • Maksim B. Gorobeyko
  • Rivaz M. Sichynava


The aim of study was to compare clinical and pathologic findings of surgically removed thyroid tumors in adults with or without history of irradiation due to the Chernobyl accident. From 1990 to 2003, 2363 adults with no evidence of radiation influence in their history (group A) have undergone operation for thyroid nodules. During the same period, 311 patients (born before 1969) with strict evidence of Chernobyl irradiation also underwent operation (group B). Both groups were similar in age, sex, and preoperative examination. Group B represented three of the four official categories of people affected by the Chernobyl accident: 1–recovery operation workers; 2–people evacuated from the restricted area; 3–inhabitants of contaminated areas. The rate of thyroid carcinoma among all cases of thyroid nodules was significantly higher in group B—32.8% (102 patients) versus 27.2% (644 patients) in group A (p < 0.05). But a more distinct difference was observed in 1 and 2 categories of group B patients (the rate of cancer was, correspondingly, 54.8% and 47.8%; p < 0.01). The percentage of the invasive form of cancer (T4) was significantly higher in irradiated patients–39% versus 23% (p < 0.05) as were regional metastases (N1a-1b)—41% versus 19% (p < 0.01) and frequency of multifocality (33% versus 24%; p < 0.05). The most distinguished features were found in 1 category of group B: T4—in 47%, N1a-1b —in 62%, multifocality—in 41%. Our results suggest the irradiation as a cause of thyroid cancer in adult victims of Chernobyl and confirm the increasing aggressiveness of such tumors.


  1. 1.
    UNSCEAR Report 2000 to the General Assembly. Annex J. Exposures and effects of the Chernobyl Accident. Int. J. Radiat. Med. 2000;6 :3-109Google Scholar
  2. 2.
    Ilyin, L, Balaonov, M, Buldakov, L,  et al. 1990Radio-contamination patterns and possible health consequences of the accident at the Chernobyl nuclear power stationJ. Radiol. Prot.10329CrossRefGoogle Scholar
  3. 3.
    Viswanathan, K, Gierlowski, T, Schneider, A 1994Childhood thyroid cancer. Characteristics and long-term outcome in children irradiated for benign conditions of the head and neckArch. Pediatr. Adolesc. Med.148260265PubMedGoogle Scholar
  4. 4.
    Franceschi, S, Boyle, P, Maisonneuve, P,  et al. 1993The epidemiology of thyroid carcinomaCrit. Rev. Oncol.42553Google Scholar
  5. 5.
    Ron, E, Lubin, J, Shore, RE 1995Thyroid cancer after exposure to external radiation: a pooled analysis of seven studiesRadiat. Res.141259277PubMedGoogle Scholar
  6. 6.
    Thompson, DE, Mabuchi, K, Ron, E,  et al. 1994Cancer incidence in atomic bomb survivors. Part II: Solid tumours, 1958-1987Radiat. Res.1971767Google Scholar
  7. 7.
    Franklyn, JA, Maisonneuve, P, Sheppard, M,  et al. 1999Cancer incidence and mortality after radioiodine treatment for hyperthyroidism; a population-based cohort studyLancet35321112115CrossRefPubMedGoogle Scholar
  8. 8.
    Ron, E, Doody, MM, Becker, DV,  et al. 1998Cancer mortality following treatment for adult hyperthyroidismJ.A.M.A.280347355CrossRefPubMedGoogle Scholar
  9. 9.
    Cherenko, SM, Larin, AS, Gorobeyko, MB,  et al. 2003Experience of surgical treatment of thyroid cancer in patients of children and adolescent age (at the moment of Chernobyl accident)Int. J. Radiat. Med.52427Google Scholar
  10. 10.
    Tronko, M, Bogdanova, T, Komissarenko, I,  et al. 1999Thyroid carcinoma in children and adolescents in Ukraine after the Chernobyl nuclear accident: statistical data and clinicomorphologic characteristicsCancer86149156CrossRefPubMedGoogle Scholar

Copyright information

© Société Internationale de Chirurgie 2004

Authors and Affiliations

  • Sergiy M. Cherenko
    • 1
  • Oleksandr S. Larin
    • 1
  • Maksim B. Gorobeyko
    • 1
  • Rivaz M. Sichynava
    • 1
  1. 1.Department of Endocrine Surgery, Ukrainian Scientific and Practical Center of Endocrine SurgeryTransplantation of Endocrine Organs and Tissues of Public Health MinistryKyivUkraine

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