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World Journal of Surgery

, Volume 25, Issue 6, pp 693–696 | Cite as

Cryoablation, Percutaneous Alcohol Injection, and Radiofrequency Ablation for Treatment of Neuroendocrine Liver Metastases

  • Allan E. Siperstein
  • Eren Berber
Article

Abstract.

Neuroendocrine liver metastases are associated with slow clinical progression, prolonged patient survival, and symptoms of hormone oversecretion. Although surgical resection is the gold standard of treatment, most of the patients are not candidates for resection, and the 5-year survival of patients with neuroendocrine liver metastases is 11% to 40%. Cryotherapy, percutaneous alcohol injection, and radiofrequency thermal ablation are among the alternative regional treatment options available for these patients. The current role of these treatment options for neuroendocrine liver tumors are discussed in this review. Cryosurgery is the classic technique for local tumor destruction, mostly performed with open surgery. There has been limited experience with percutaneous alcohol injection for neuroendocrine liver metastasis. Radiofrequency thermal ablation is a relatively new modality that can be performed percutaneously or laparoscopically, and encouraging results have been obtained with it for treatment of neuroendocrine liver metastases.

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Copyright information

© Société Internationale de Chirurgie 2001

Authors and Affiliations

  • Allan E. Siperstein
    • 1
  • Eren Berber
    • 1
  1. 1.Department of General Surgery/A80, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USAUS

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