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A Meta-analysis-Based Assessment of Intense Pulsed Light for Treatment of Melasma

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Abstract

Background

A safe and effective treatment for melasma, an acquired refractory pigmented skin disease, remains a problem, although numerous clinical trials have explored the possibility of combined therapy involving intense pulsed light. To date, little is known regarding the efficacy of this treatment. The current study, therefore, sought to explore the effectiveness of intense pulsed light.

Methods

We used published studies from literature databases, based on established inclusion criteria, to calculate standardized mean differences (SMDs) and risk ratio (RRs), and evaluated the effectiveness of combined therapy with intense pulsed light in melasma patients. We performed data analysis using the Review Manager 5.3 software at 95% confidence interval.

Results

We obtained a total of 8 studies, involving 215 patients, from the databases and found a significant effect on efficacy following combined therapy with intense pulsed light. Specifically, the melasma area and severity index (MASI) score was significantly low (SMD = 0.61, CI [0.42, 0.80] P < 0.0001 for a fixed-effects model), while a four-point scoring scale self-assessment by patients was significantly high (RR = 1.44, CI [1.17, 1.76] P = 0.0004 for a fixed-effects model).

Conclusion

Our meta-analysis showed that IPL-based combination therapy for melasma can effectively reduce the MASI score and result in higher satisfaction among patients, indicating an effective method for treatment of the condition.

Level of Evidence III

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Acknowledgements

All the co-authors performed analysis procedures and participated in writing of the manuscript.

Funding

This work was supported by the Special Foundation of Basic Science and Technology Resources Survey of Ministry of Science and Technology of China (2017FY101204) and the Scientific Research Fund Project of Hunan Provincial Health Commission (B2015-040).

Author information

Correspondence to Jianda Zhou.

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Conflict of interest

The authors have no conflicts of interest to disclose.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

Informed consent was not required for this study.

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Yi, J., Hong, T., Zeng, H. et al. A Meta-analysis-Based Assessment of Intense Pulsed Light for Treatment of Melasma. Aesth Plast Surg (2020). https://doi.org/10.1007/s00266-020-01637-x

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Keywords

  • Intense pulsed light
  • Melasma
  • Meta-analysis