Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): An Open Wound
Since 2017, there have been an increasing number of reported cases regarding breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in the literature. Although significant attention was dispensed for this relevant issue, there is no consensus on what the trigger points for disease development are. BIA-ALCL trigger point speculation includes textured breast implants, bacterial contamination, and genetic factors. However, little attention is given by the literature regarding gel bleeding and the toxicity of polydimethylsiloxane. This opinion-based article aims to report our experience in a prospective study of breast implants and share our knowledge regarding silicone-induced granuloma of breast implant capsule.
Level of Evidence V
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
The author acknowledges Dr. Gabriel Salum D’Alessandro, who made the capsulectomy and the implant explantation.
There is no funding support.
Compliance with Ethical Standards
Conflict of interest
There is no competing interest.
Waived due to the type of manuscript.
Informed consent was obtained from the patient.
- 2.Fleury EF, Rêgo MM, Ramalho LC, Ayres VJ, Seleti RO, Ferreira CAP et al (2017) Silicone-induced granuloma of breast implant capsule (SIGBIC): similarities and differences with anaplastic large cell lymphoma (ALCL) and their differential diagnosis. Breast Cancer Targets Ther 9:133–140. https://www.dovepress.com/silicone-induced-granuloma-of-breast-implant-capsule-sigbic-similariti-peer-reviewed-article-BCTT. Cited 19 Mar 2017
- 9.de Faria Castro Fleury E, Alessandro GSD, Cristina S, Wludarski L (2018) Silicone-induced granuloma of breast implant capsule (SIGBIC): histopathology and radiological correlation. J Immunol Res 20:6784971Google Scholar