Effect of a Formulation Containing Low-Dose Sodium Deoxycholate on Local Fat Reduction
- 74 Downloads
Synthetic deoxycholic acid (DCA) has been approved as an injectable drug for the nonsurgical reduction of submental fat.
In this study, we evaluated the fat-reducing effects of a new formula containing a low dose of DCA and fat dissolution by topical application of DCA.
Sodium deoxycholate (99.1% pure) and the new formulation containing 10% DCA were injected or topically applied to the dorsa of obese mice (induced by a high-fat diet). The rate of change in body weight was evaluated, together with comparisons of micro-computed tomography images, body composition measurements, and histology findings.
The results showed that the new formula containing low-dose DCA was as effective as the older high-dose formulation with respect to the rate of change in body weight and reductions in subcutaneous fat pad area, body fat weight, and the thickness of the subcutaneous fat layer. Furthermore, topical application of the high-dose, but not the low-dose, formulation yielded promising effects.
The development of a better protocol for the high-dose preparation, including dose optimization and application methods that minimize the adverse effects of DCA, merits further study.
No Level Assigned
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine Ratings, please refer to Table of Contents or online Instructions to Authors - www.springer.com/00266 .
KeywordsDeoxycholate Lipolysis Subcutaneous fat
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest to disclose.
Human and Animal Rights
The animal care and experimental procedures were approved by the Institutional Animal Care and Use Committee.
For this type of study, informed consent is not required.
- 1.Ginsberg HN, MacCallum PR (2009) The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus. J Cardiometab Syndr 4:113–119CrossRefGoogle Scholar
- 5.Humphrey S, Beleznay K, Beleznay JD (2016) Sodium deoxycholate for submental contouring. Skin Ther Lett 21:1–4Google Scholar