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Aesthetic Plastic Surgery

, Volume 43, Issue 6, pp 1603–1606 | Cite as

The Hemostatic Effect of Desmopressin on Bleeding as a Nasal Spray in Open Septorhinoplasty

  • Shahriar Haddady-Abianeh
  • Ahmad Ali Rajabpour
  • Mehdi Sanatkarfar
  • Mohammad Reza Farahvash
  • Ghasemali Khorasani
  • Hojjat MolaeiEmail author
Original Article Rhinoplasty
  • 100 Downloads

Abstract

Background

Rhinoplasty is associated with intraoperative bleeding which affects the quality of the operation and may increase the time of surgery. The aim of this study was to assess the role of nasal spray of desmopressin on reduction in intraoperative bleeding during elective open rhinoplasty.

Methods

Conducting an interventional study in our hospital, all patient data including demographic information, medical history and laboratory tests before surgery were collected. Patients who were randomly divided into two study groups, received nasal desmopressin spray or placebo spray, 60 min before starting open septorhinoplasty. The measured variables included: bleeding volume, the operative field quality in regard to bleeding (Boezaart score), the surgeons' satisfaction in regard to bleeding during surgery (Likert scale), postoperative bruising, postoperative bleeding and menstruation.

Results

Thirty cases were studied; 13 (46.3%) people received placebo and 17 (56.7%) received desmopressin. The Boezaart score, satisfaction scores, bleeding volume, upper eyelid ecchymosis in the group receiving desmopressin were significantly better than the control group. Postoperative bleeding was also less in the desmopressin group, but not significant as other variables. In women of each group, menstruation had no effect on the amount of bleeding, surgical field quality and surgeon satisfaction compared with non-menstruation women.

Conclusion

Nasal desmopressin use is an effective method for reducing intraoperative and postoperative bleeding and diminished postoperative ecchymosis which improves surgeons’ satisfaction. So using the nasal form of desmopressin could be considered as method of controlling bleeding and ecchymosis in open rhinoplasty.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Notes

Acknowledgements

The authors thank Muhammed Hussein Mousavinasab for editing this text.

Funding

None.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interests.

Ethical Approval

This article was based on fellowship thesis accepted by ethic committee with number: 9311256006 and all human rights were respected accordingly.

Informed Consent

All patients signed informed consents (in Persian forms) while enrolling the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2019

Authors and Affiliations

  1. 1.Department of Plastic and Reconstructive Surgery, Faculty of MedicineTehran University of Medical SciencesTehranIran
  2. 2.Department of Plastic and Reconstructive Surgery, Faculty of MedicineMazandaran University of Medical SciencesSariIran
  3. 3.Department of Anesthesiology, Faculty of MedicineTehran University of Medical SciencesTehranIran
  4. 4.Valiasr HospitalImam Khomeini Hospital ComplexTehranIran

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