Discussion: Clinical Impact of Highly Condensed Stromal Vascular Fraction Injection in Surgical Management of Depressed and Contracted Scars

  • Seong Joo Lee
  • In Suck Suh
  • Hii Sun JeongEmail author
Editor’s Invited Commentary

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors

Dear Editors,

We appreciate your comments on our paper, in which you suggested alternatives to the enzymatic stromal vascular fraction (SVF) and safety issues. We were very interested in your opinions.

Your first comment was on the usage of type II collagenase. This enzyme is used widely for the enzymatic digestion of centrifuged fat, as it dissociates adipose cell membranes most efficiently. However, to extract stem cells from adipose tissue, it is more useful to digest the collagen rather than the adipose cell membrane. As the substrates of type II collagenase are collagen types I, III, V, VII, VIII, and X, fibronectin, gelatin, and aggrecan, this enzyme has a better harvesting effect on cells from dermal and fat tissue....


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2019

Authors and Affiliations

  1. 1.Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, College of MedicineHallym UniversitySeoulKorea

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