Aesthetic Plastic Surgery

, Volume 36, Issue 6, pp 1296–1301

Use of Autologous Fibrin Glue (Platelet-Poor Plasma) in Abdominal Dermolipectomies

  • Angélica Maria Schettino
  • Diogo Franco
  • Talita Franco
  • João Medeiros Tavares Filho
  • Fabiel Spani Vendramin
Original Article Aesthetic



Autologous plasma is endowed with properties that speed up healing, hemostasis, and adhesiveness, in addition to growth factors. Through an established protocol, it was possible to isolate thrombin, as well as the platelet-rich plasma (PRP) and platelet-poor plasma (PPP) fractions. The purpose of this study was to analyze autologous use of thrombin and PPP to foster adhesion between an abdominal dermoadipose flap and the aponeurotic surface in abdominal dermolipectomies.


The data from 40 patients who underwent abdominal dermolipectomies were analyzed, with 20 patients using thrombin and autologous PPP (Plasma group) and 20 patients with no intervention (Control group). An attempt was made to assess adhesive power by quantifying the serohematic liquid volume gauged during the postoperative days (POD), and also noting the incidence of seroma. Other variables such as age and body mass index (BMI) were also analyzed.


The reduction in the aspiration drain debit was statistically relevant only on the first POD in the Plasma group. There was no reduction in the incidence of seroma in these patients. Similarly, age and BMI did not influence these outcomes.


The PPP fostered adhesion between the abdominal dermoadipose flap and the aponeurotic surface only on the first POD and had no influence whatsoever on the incidence of seroma. There are few reports on the use of PPP for plastic surgery, particularly the autologous type, opening up possibilities for further research projects to expand its use.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the table of contents or the online instructions to authors


Platelet-rich plasma Plasma Plastic surgery 


  1. 1.
    Brazilian Society of Plastic Surgeons (2009) Surgery statistics. Accessed 14 September 2010
  2. 2.
    American Society of Plastic Surgeons. National Clearinghouse of Plastic Surgery Statistics. Accessed 23 March 2011
  3. 3.
    Kim J, Stevenson TR (2006) Abdominoplasty, liposuction of the flanks and obesity: analyzing risk factors for seroma formation. Plast Reconstr Surg 117:773–779PubMedCrossRefGoogle Scholar
  4. 4.
    Di Martino M, Nahas FX, Barbosa MV, Montecinos Ayaviri NA, Kimura AK, Barella SM, Novo NF, Ferreira LM (2010) Seroma in lipoabdominoplasty and abdominoplasty. a comparative study using ultrasound. Plast Reconstr Surg 126(5):1742–1751PubMedCrossRefGoogle Scholar
  5. 5.
    Marchac D, Sándor G (1994) Face lifts and sprayed fibrin glue: an outcome analysis of 200 patients. Br J Plast Surg 47:306–309PubMedCrossRefGoogle Scholar
  6. 6.
    Rasedovich M, Goubran HA, Burnouf T (1997) Fibrin sealant: scientific rationale, production methods, properties and current clinical use. Vox Sang 72:133–143CrossRefGoogle Scholar
  7. 7.
    Marx RE (2004) Platelet rich plasma: evidence to support its use. J Oral Maxillofac Surg 62:489–496PubMedCrossRefGoogle Scholar
  8. 8.
    Marx RE, Carlson ER (1998) Platelet-rich plasma: growth factors enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:638–646PubMedCrossRefGoogle Scholar
  9. 9.
    Man D, Plosker H, Winland-Brown JE (2001) The use of autologous platelet rich plasma (platelet gel) and autologous platelet poor plasma (fibrin glue) in cosmetic surgery. Plast Reconstr Surg 107:229–237PubMedCrossRefGoogle Scholar
  10. 10.
    Bozola AC, Bozola AR (2003) Abdominoplastias. In: Mélega JM (ed) Cirurgia plástica: fundamentos e arte. São Paulo, Medsi, pp 609–623Google Scholar
  11. 11.
    Vendramin FS, Franco D, Nogueira CM, Pereira MS, Franco T (2006) Plasma rico em plaquetas e fatores de crescimento: técnica de preparo e utilização em cirurgia plástica. Rev Col Bras Cir 33:24–28CrossRefGoogle Scholar
  12. 12.
    Eppley BL, Woodell JE, Higgins J (2004) Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 114:1502–1508PubMedGoogle Scholar
  13. 13.
    Vendramin FS, Franco D, Franco T (2010) Utilização de plasma rico em plaquetas autólogo nas cirurgias de enxertos cutâneos em feridas crônicas. Rev Bras Cir Plast 25:589–594CrossRefGoogle Scholar
  14. 14.
    Grageda E (2004) Platelet-rich plasma and bone graft materials: a review and a standardized research protocol. Implant Dentistry 13:301–309PubMedGoogle Scholar
  15. 15.
    Kazakos K, Lyras DN, Verettas D, Tilkeridis K, Tryfonidis M (2009) The use of autologous PRP gel as an aid in the management of acute trauma wounds. Injury 40:801–805PubMedCrossRefGoogle Scholar
  16. 16.
    Zucchelli P, Silvestri AR (2004) Production and use of fibrin glue at blood transfusion service of Bellaria-Maggiore Hospital Bologna. Transfus Apher Sci 30:157–161PubMedCrossRefGoogle Scholar
  17. 17.
    Findikcioglu K, Findikcioglu F, Yavuzer R, Elmas C, Atabay K (2009) Effect of platelet rich plasma and fibrin glue on healing critical-size calvarian bone defects. J Craniofac Surg 20:34–40PubMedCrossRefGoogle Scholar
  18. 18.
    Albanyan AM, Sukhu K, Harrison P (2009) Evoluation of the PDQ centrifuge for preparing platelet rich, platelet poor and platelet free plasma samples for light transmition aggregometry and microparticle measurement. Platelets 20:610–612PubMedCrossRefGoogle Scholar
  19. 19.
    Bhanot S, Alex JC (2002) Current application of platelet gels in facial plastic surgery. Facial Plast Surg 18:27–33PubMedCrossRefGoogle Scholar
  20. 20.
    Petrungaro PS (2001) Using platelet rich plasma to accelerate soft tissue maturation in aesthetic periodontal surgery. Compend Contin Educ Dent 22:729–736PubMedGoogle Scholar
  21. 21.
    Tischler M (2002) Platelet rich plasma. The use of autologous growth factors to enhance bone and soft tissue grafts. NY State Dent J 68:22–24Google Scholar
  22. 22.
    Mann KG (2003) Thrombin formation. Chest 124:4S–10SPubMedCrossRefGoogle Scholar
  23. 23.
    Taube J, McWilliam N, Luddington R, Byrne CD, Baglin T (1999) Actived protein C resistance: effect of platelet activation, platelet-derived microparticles and atherogenic lipoproteins. Blood 11:3792–3797Google Scholar
  24. 24.
    Saldanha OR, Pinto EBDS, Mattos Júnior WN, Pazetti CE, Bello EML (2003) Lipoabdominoplasty with selective and safe undermining. Aesthet Plast Surg 27:322–327CrossRefGoogle Scholar
  25. 25.
    Baroudi R, Ferreira CAA (1998) Seroma: how to avoid it. Aesthet Surg J 18:439–441PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2012

Authors and Affiliations

  • Angélica Maria Schettino
    • 1
    • 2
  • Diogo Franco
    • 1
  • Talita Franco
    • 1
  • João Medeiros Tavares Filho
    • 1
  • Fabiel Spani Vendramin
    • 3
  1. 1.Federal University of Rio de JaneiroRio de JaneiroBrazil
  2. 2.Marcilio Dias Navy Hospital Rio de JaneiroBrazil
  3. 3.Federal University of ParáBelémBrazil

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