Aesthetic Plastic Surgery

, Volume 37, Issue 2, pp 409–416

Madelung’s Disease: Comorbidities, Fatty Mass Distribution, and Response to Treatment of 22 Patients

  • Beatriz Brea-García
  • José Cameselle-Teijeiro
  • Ivan Couto-González
  • Antonio Taboada-Suárez
  • Eduardo González-Álvarez
Original Article General Reconstruction

DOI: 10.1007/s00266-012-9874-5

Cite this article as:
Brea-García, B., Cameselle-Teijeiro, J., Couto-González, I. et al. Aesth Plast Surg (2013) 37: 409. doi:10.1007/s00266-012-9874-5

Abstract

Background

Madelung’s disease (MD) is an uncommon pathology characterized by the presence of multiple masses of unencapsulated adipose tissue that is symmetrically distributed. The aim of this study was to investigate clinical and epidemiological features of patients diagnosed with MD in our department. Associated diseases and evolution after treatment were also investigated.

Methods

We reviewed the clinical histories of 22 patients diagnosed with MD from 1990 to 2010 and obtained their epidemiological and clinical characteristics.

Results

We found 21 patients with MD type 1 and one patient with MD type 2 according to Enzi’s classification. All patients were male, 95.5% with high alcohol intake, and 59.1% with some hepatic disease. No family antecedents were significant; 40.9% had dyslipidemia, 22.7% arterial hypertension, 22.7% chronic obstructive pulmonary disease (COPD), 13.6% hyperuricemia, 9.1% hypothyroidism, 4.5% diabetes mellitus type 2, and 4.5% carbohydrate intolerance; 40.9% had a body mass index >30, and 27.3% presented gynecomastia/lipomastia. The region most frequently affected by fatty deposits was the neck.

Conclusions

Madelung’s disease affects mainly alcoholic males in their fourth decade of life. Hepatic diseases appear in most patients. Also associated with MD are high lipid blood levels, arterial hypertension, COPD, hyperuricemia, and obesity. MD type 1 is the most frequent phenotype and the neck the most common location for fatty masses. Recurrence after surgery, in the same location or different locations, is a frequent event, even in patients who later abstain from alcohol intake.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors at www.springer.com/00266.

Keywords

Madelung’s disease Lipomatosis Alcohol abuse Hepatic disease 

Copyright information

© Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2013

Authors and Affiliations

  • Beatriz Brea-García
    • 1
  • José Cameselle-Teijeiro
    • 2
  • Ivan Couto-González
    • 1
  • Antonio Taboada-Suárez
    • 1
  • Eduardo González-Álvarez
    • 1
  1. 1.Plastic and Reconstructive Surgery DepartmentSERGAS, Complejo Hospitalario Universitario de Santiago de CompostelaSantiago de CompostelaSpain
  2. 2.Anatomic Pathology DepartmentSERGAS, Complejo Hospitalario Universitario de Santiago de CompostelaSantiago de CompostelaSpain

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