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Aesthetic Plastic Surgery

, Volume 35, Issue 6, pp 1022–1030 | Cite as

Autologous Cell-Enriched Fat Grafting for Breast Augmentation

  • Tatsuro Kamakura
  • Kohei Ito
Original Article

Abstract

Autologous fat grafting for breast augmentation has faced some historical hurdles. However, in recent years it has been gaining acceptance from the medical community. This prospective, nonrandomized open-label study of 20 Japanese women supports the use of autologous fat grafting in breast augmentation and explores enhancement of fat graft tissue with autologous adipose-derived regenerative cells (ADRCs). After adipose harvesting using syringe liposuction, the tissue is processed in the Celution 800 System®, which washes the graft and isolates ADRCs. The average cells per gram of harvested adipose tissue was 3.42 × 105, and the mean cell viability measured using an automated cell counting system before graft delivery was 85.3%. All patients demonstrated improvement in circumferential breast measurement (BRM) from their baseline state, and breast measurements were stable by 3 months after surgery. The mean BRM 9 months after surgery had increased 3.3 cm from preoperative measurements. Through 9 months, overall physician satisfaction was 69% and patient satisfaction was 75%. No serious or unexpected adverse events were reported, and the procedure was safe and well tolerated in all patients. Postoperative cyst formation was seen in two patients. These prospective results demonstrate that ADRC-enriched fat grafts processed with a closed automated system maintain high cell viability and that the procedure is safe and effective, with all patients showing improvement after a single treatment.

Keywords

Adipose-derived regenerative cells Adipose tissue graft Autologous fat graft Breast augmentation Cell-enriched graft Celution Stem cells 

Notes

Acknowledgment

Editorial assistance and technical support for the Celution 800 System® were provided by Cytori Therapeutics. The authors have no other conflicts of interest and did not receive any other support, financial or otherwise, from Cytori Therapeutics.

Conflict of interest

The authors have no other conflicts of interest and did not receive any other support, financial or otherwise, from Cytori Therapeutics.

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Copyright information

© Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2011

Authors and Affiliations

  1. 1.Cosmetic Surgery SeishinTokyoJapan

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