Systemic Inflammatory Reaction After Silicone Breast Implant
- 344 Downloads
Systemic inflammation after augmentation mammaplasty with modern silicone implants is not currently recognized. In a prospective controlled study, C-reactive protein and other variables were monitored, aiming to test this hypothesis in a young cohort of patients.
Females (18-30 years old, BMI = 18.5-30 kg/m2, N = 52) were consecutively recruited for breast implant (n = 24, Group I) and for abdominal liposuction (n = 28, Group II/Controls). Patients were interviewed at baseline and followed until 6 months after operation. Variables included demographic and clinical information, surgical outcome, inflammatory markers and autoantibodies.
Operations were well tolerated, without surgical or infectious complications. Mean prosthesis size was 258 ± 21 ml (range = 220-280) and mean aspirate of liposuction was 1972 ± 499 ml (range = 1200-3000). Preoperative, 2-month, and 6-month C-reactive protein concentrations for breast implant patients were 1.3 ± 1.2, 4.8 ± 3.0, and 4.3 ± 6.4 mg/l and for liposuction 3.5 ± 2.7, 3.5 ± 2.1, and 2.2 ± 2.2 mg/l, respectively. Change at 2 months was significant (p = 0.001). Autoantibody investigation failed to reveal remarkable aberrations, except for anticardiolipin elevation, which was nearly symmetrical in the two groups.
C-reactive protein levels increased after operation and correlated with proinflammatory and procoagulatory indices. A mild increase in anticardiolipin IgM occurred but differences between populations were lacking. Despite excellent cosmetic outcomes and lack of complications, acute phase reaction could signal ongoing immunogenicity of silicone and long-term monitoring is recommended.
KeywordsAugmentation mammaplasty Silicone breast implant Inflammatory reaction Autoantibodies C-reactive protein Cosmetic breast surgery
- 5.Bondurant S, Ernster V, Herdman R (eds) (1999) Institute of Medicine (US) Committee on the Safety of Silicone Breast Implants: safety of silicone breast implants. National Academies Press, WashingtonGoogle Scholar
- 9.ASAPS (2010) www.surgery.org/sites/default/files/statsquickfacts.pdf. Accessed 27 Dec 2010
- 15.U.S. FDA (2010) Medical devices, breast implants. Available at www.fda.gov/cdrh/breastimplants/labeling/mentor_patient_labeling_5900.html#9. Accessed 27 Dec 2010
- 22.Seyhan H, Kopp J, Beier JP, Vogel M, Akkermann O, Kneser U, Schwartz S, Hartmann A, Horch RE (2011) Smooth and textured silicone surfaces of modified gel mammary prostheses cause a different impact on fibroproliferative properties of dermal fibroblasts. J Plast Reconstr Aesthet Surg 64(3):e60–e66PubMedCrossRefGoogle Scholar