A New Approach for Adipose Tissue Treatment and Body Contouring Using Radiofrequency-Assisted Liposuction
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A new liposuction technology for adipocyte lipolysis and uniform three-dimensional tissue heating and contraction is presented. The technology is based on bipolar radiofrequency energy applied to the subcutaneous adipose tissue and subdermal skin surface. Preliminary clinical results, thermal monitoring, and histologic biopsies of the treated tissue demonstrate rapid preaspiration liquefaction of adipose tissue, coagulation of subcutaneous blood vessels, and uniform sustained heating of tissue.
KeywordsCoagulation Liposuction Radiofrequency Tightening
We live in a culture preoccupied with both weight and body contour. North America also is a society in which obesity is an epidemic. It is no surprise then that liposuction continues to be the most commonly performed aesthetic procedure in the world. In 2007, 450,000 liposuction procedures were performed in the United States alone by board-certified plastic surgeons, and another 150,000 by nonplastic surgeon physicians, for a total 600,000 lipocontouring procedures, accounting for approximately 5% of all elective surgeries in the United States. It is estimated that the number of liposuction procedures will more than double over the next 5 years.
Coincident with the dramatic rise in liposuction procedures, the aging “baby boomer” population, with decreasing skin tone and advanced laxity, are seeking body contour procedures. A technology that effectively allows the physician to remove and contour adipose tissue with less bruising, swelling, and pain while simultaneously providing for significant soft tissue contraction would enjoy popular appeal.
Traditional tumescent, small-cannula, suction-assisted liposuction (SAL) is based on mechanical disruption of adipose tissue by a suction cannula moved manually through the subcutaneous space aspirating small fat clusters of adipose tissue through the openings in the cannula [4, 9, 11, 12, 21]. This traditional liposuction procedure of avulsing fat through a mechanically induced negative pressure requires a degree of effort on the part of the physician and can be quite traumatic for the patient.
Traditional SAL is less effective in secondary liposuction procedures and in fibrous areas, which do not enjoy significant skin contraction [13, 14]. The evolution of smaller vented cannulas, wetting solutions, and syringe aspiration techniques has refined the art of liposuction [5, 6, 7, 13, 14, 16, 17, 18, 22]. In an attempt to improve the postoperative patient recovery profile of pain, swelling, and bruising, and to enhance skin contraction, physician effort, and effectiveness in secondary and fibrous cases, newer generations of energy-assisted liposuction technologies have been developed.
The technique of ultrasound-assisted liposuction, in which cavitational ultrasound energy is delivered through a probe to adipose tissue specifically cavitated and liquified, is shown to be less traumatic than SAL and may result in more skin contraction [2, 15, 20, 23, 24]. Power-assisted liposuction (PAL) is a commonly used technology that uses a variable-speed motor to provide reciprocating motion to the cannula, which in combination with the reciprocating action of the surgeon’s arm, facilitates removal of adipose tissue . The principal advantage of PAL is treatment speed and economy of motion.
Most recently, laser-assisted lipolysis (LAL) has been popularized [1, 8, 10, 19]. With the LAL technique, small fiberoptic probes deliver thermal and micromechanical lipolysis to adipose tissue, reducing the need for traumatic adipose aspiration forces and pressures and leading to an improved recovery profile for the patient. One of the purported LAL benefits is enhanced skin contraction after application of the small fiber to the subdermal space and warming of the skin to a temperature of 40°C [1, 8, 10, 19].
Although LAL became popular because of a strong campaign directly to consumers highlighting diminished recovery pain and risk as well as the potential ability to tighten the skin through subdermal heating, its use remains limited by relatively slow treatment speed, poor control of heating uniformity, and risk of tissue burns.
Reduced tissue trauma
Uniform heating of the skin and the subcutaneous layer
Potential skin contraction.
Materials and Methods
No. of cases
In this study, electrode size and applied power were adjusted to provide adipose tissue liquefaction in the tissue between the internal and external electrodes and subnecrotic heating in the skin. Online, continuous skin temperature measurements with a negative feedback loop control of power were conducted by a temperature sensor embedded in the external electrode and confirmed by thermal camera FLIR A320 (FLIR Systems, Sausalito, CA).
Continuous online tissue impedance and power output between electrodes were monitored. During treatment, the parameters of the BodyTite device were set so that the system would reach 40°C and maintain that target temperature for 1 to 2 min. The typical RF energy introduced into the treated area was 100 J/cm2. Uniformity of temperature distribution was analyzed using thermal images and Researcher 2.9 of Flir Systems software.
In addition, two patients underwent RFAL to their lower abdominal tissue immediately before excision of this tissue through an abdominoplasty procedure. Several 6-mm excisional biopsies were taken at the end of the treatment to analyze the RFAL treatment effect on fat and skin. A control biopsy was taken from an immediately adjacent untreated area.
Uniform temperature distribution (±2°C)
Ability to maintain desired contraction temperatures for a consistent duration of time
Coagulation and liquefaction of adipose tissue
Blood vessel coagulation in the adipose layer.
The areas to be contoured were divided into distinct thermal zones of 10 × 15 cm. The discrete thermal zones corresponded to the length of the internal electrode and were selected to ensure a quick uniform adipose and vascular coagulation and a rise in temperature. Zones were selected and marked on the patient’s body. The cutoff temperature was set as high as 42°C. When measured skin temperature reached this thermal target point, the device automatically cut off the power and restored power only when the temperature fell below the preset value. The power used for treatment in each zone was set initially to 20 W and increased gradually up to 50 W if no warning signs such as temperature spikes, erythema, or intradermal vesicles were observed. After determination of the maximal safety power level, the zone was treated with RFAL until the temperature-controlled power cutoff limit was reached, which then was maintained at this level for 1 to 2 min to ensure uniform heating. Typical treatment power was 40 to 45 W.
Two depth settings were used for the treatment. The depth of 30 to 45 mm was used for treatment of deep fat. The end point for deep fat was reduction of mechanical tissue resistance. The superficial layer then was treated using a depth preset at 10 to 25 mm. A uniform desired tissue temperature elevation was the indication of successful treatment.
After the RF treatment, aspiration of the coagulated adipose tissue was performed using a standard vented microcannula. Aspiration and contouring of the zone was completed when the “pinch and roll” test indicated symmetric, even, and uniform fat reduction. Fat thickness, treated area, and total applied energy were documented to determine the volumetric RF dose required to perform the treatment according to the aforementioned criteria.
We compared the thermal effect created using RFAL BodyTite technology with the effect of LAL (SmartLipo MPX, Cynosure, Westford, MA) as the standards for thermal and nonthermal lipolysis and lipoplasty. For the speed of treatment, the gold standard remains PAL (Microaire Surgical Instruments, Charlottesville, VA).
The initial temperature of the treatment sites varied from 26 to 29°C. At a power output of 45 W, it took approximately 8 to 12 min to heat up a typical zone with a thermal zone of 15 × 10 cm and a thickness of 25 mm. This treatment speed of uniform heating is much faster than that of the available LAL devices. We believe that the high speed of treatment is achieved not only by the higher power of the device, but also from the more efficient use of applied power, which is not scattered from the treatment tip in all directions but concentrated in the treated zone between the two electrodes. The high speed of tissue heating facilitates the treatment of patients with large or multiple anatomic zones. In the current study, the treatment speed was comparable with that of ultrasound-assisted liposuction devices, but we believe that combination RFAL handpieces with simultaneous aspiration will make the treatment speed comparable with that of PAL.
Volumetric analysis of applied energy and treated volume showed that approximately 50 J/cm3 is required to reach the needed thermal effect in a lipoplasty zone of standard size. At an RF power of 40 to 50 W, the speed of volumetric treatment is in the range of 1 to 1.2 s/cm3.
Ease of Use
For a thermal sensor embedded in the external electrode, anticarbonization protection of the internal electrode and treatment depth control makes treatment safe, effective, and easy.
Uniformity of Temperature Distribution
It can be seen that PAL creates channels in the adipose tissue with strong bleeding (Fig. 6b). Erythrocytes fill most of the space between fat cells. After RF-assisted treatment, the channel is free of blood, and strong fat cell membrane defragmentation is observed.
Blood Vessel Coagulation
Collagen Tissue and Skin Contraction
No complications or any long-lasting negative side effects were observed for any patients. All the patients experienced minimal pain, swelling, and ecchymosis. It is postulated that the reduced bruising observed was due to blood vessel coagulation in the treated zone before aspiration. The feedback control in the BodyTite handpiece allowed for the necessary sustained tissue heating to 40 to 42°C without thermal injury.
Ability to heat a significant volume of tissue quickly and uniformly
Ability to control tissue heating through direct monitoring of temperature and tissue impedance.
Defragmentation of fat cells and coagulation of blood vessels in the treated zone, reducing bleeding and bruising
Obvious collagen denaturation after RFAL treatment
Significant contraction and retraction of adipose and dermal tissue after treatment.
The correlation between tissue-heating temperature, time, and body tightening requires further investigation but appears to offer an exciting new vista in nonexcisional body contouring.
We thank Invasix Ltd for assistance in thermal measurements, and we appreciate Patricia Ganas for her assistance with preparing this report for publication. The chief of medical advisory board was compensated for fees and options by Invasix Ltd.
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