Clinical Efficacy of Noninvasive Cryolipolysis and Its Effects on Peripheral Nerves
Cryolipolysis provides a method for noninvasive fat reduction that significantly reduces subcutaneous fat in a pig model without apparent damage to skin and surrounding structures. This study aimed to determine whether fat reduction in humans caused by cold exposure is associated with alteration in local sensory function or nerve fibers.
In this study, 10 subjects were treated with a prototype cooling device. Fat reduction was assessed in 9 of the 10 subjects via ultrasound before treatment and at the follow-up visit. Sensory function was assessed by neurologic evaluation (n = 9), and biopsies (n = 1) were collected for nerve staining.
Treatment resulted in a normalized fat layer reduction of 20.4% at 2 months and 25.5% at 6 months after treatment. Transient reduction in sensation occurred in six of nine subjects assessed by neurologic evaluation. However, all sensation returned by a mean of 3.6 weeks after treatment. Biopsies showed no long-term change in nerve fiber structure. There were no lasting sensory alterations or observations of skin damage in any of the subjects evaluated.
Noninvasive cryolipolysis results in substantial fat reduction within 2 months of treatment without damage to skin. The procedure is associated with modest reversible short-term changes in the function of peripheral sensory nerves.
KeywordsCryolipolysis Efficacy Fat reduction Neurologic effects Noninvasive
The authors thank William Kennedy, MD, of the Kennedy Laboratory, Department of Neurology at the University of Minnesota for study guidance and histologic analysis, and Eric Okamoto, MD, of Fremont Plastic and Cosmetic Surgery, California, and Jeffrey Riopelle, MD, of Laser Advantage (Medi Spa) at San Ramon, California, for contributing subjects to the study. This research was funded by Zeltiq Aesthetics.
- 1.Manstein D, Laubach H, Watanabe K, Anderson RR (2008) A novel cryotherapy method of non-invasive, selective lipolysis. Lasers Surg Med S20(40):104Google Scholar
- 2.Preciado J, Allison J (2008) The effect of cold exposure on adipocytes: examining a novel method for the noninvasive removal of fat. Oral presentation at the society for cryobiology annual meeting, 21 July 2008Google Scholar
- 10.Shurtleff D, Gilliatt RW, Thomas JR, Pezeshkpour GH (1993) An assessment of peripheral nerve damage in the rat following nonfreezing cold exposure: an electrophysiological and histopathologic examination. Technical report, Jan 1991–Jan 1992. Naval Medical Research Institute: Bethesda, MD. http://stinet.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=ADA264293