Aesthetic Plastic Surgery

, Volume 33, Issue 4, pp 482–488 | Cite as

Clinical Efficacy of Noninvasive Cryolipolysis and Its Effects on Peripheral Nerves

  • Sydney R. Coleman
  • Kulveen Sachdeva
  • Barbara M. Egbert
  • Jessica Preciado
  • John Allison
Original Article

Abstract

Background

Cryolipolysis provides a method for noninvasive fat reduction that significantly reduces subcutaneous fat in a pig model without apparent damage to skin and surrounding structures. This study aimed to determine whether fat reduction in humans caused by cold exposure is associated with alteration in local sensory function or nerve fibers.

Methods

In this study, 10 subjects were treated with a prototype cooling device. Fat reduction was assessed in 9 of the 10 subjects via ultrasound before treatment and at the follow-up visit. Sensory function was assessed by neurologic evaluation (n = 9), and biopsies (n = 1) were collected for nerve staining.

Results

Treatment resulted in a normalized fat layer reduction of 20.4% at 2 months and 25.5% at 6 months after treatment. Transient reduction in sensation occurred in six of nine subjects assessed by neurologic evaluation. However, all sensation returned by a mean of 3.6 weeks after treatment. Biopsies showed no long-term change in nerve fiber structure. There were no lasting sensory alterations or observations of skin damage in any of the subjects evaluated.

Conclusion

Noninvasive cryolipolysis results in substantial fat reduction within 2 months of treatment without damage to skin. The procedure is associated with modest reversible short-term changes in the function of peripheral sensory nerves.

Keywords

Cryolipolysis Efficacy Fat reduction Neurologic effects Noninvasive 

References

  1. 1.
    Manstein D, Laubach H, Watanabe K, Anderson RR (2008) A novel cryotherapy method of non-invasive, selective lipolysis. Lasers Surg Med S20(40):104Google Scholar
  2. 2.
    Preciado J, Allison J (2008) The effect of cold exposure on adipocytes: examining a novel method for the noninvasive removal of fat. Oral presentation at the society for cryobiology annual meeting, 21 July 2008Google Scholar
  3. 3.
    Rispat G, Slaoui M, Weber D, Salemink P, Berthoux C, Shrivastava R (1993) Haematological and plasma biochemical values for healthy Yucatan micropigs. Lab Anim 27:368–373PubMedCrossRefGoogle Scholar
  4. 4.
    Kennedy WR, Wendelschafer-Crabb G, Polydefkis M, McArthur JC (2005) Pathology and quantitation of cutaneous innervation. In: Dyck PJ, Thomas PK (eds) Peripheral neuropathy. Elsevier, Philadelphia, PA, pp 869–895CrossRefGoogle Scholar
  5. 5.
    Kennedy WR, Wendelschafer-Crabb G, Johnson T (1996) Quantitation of epidermal nerves in diabetic neuropathy. Neurology 47:1042–1048PubMedGoogle Scholar
  6. 6.
    Nolano M, Simone DA, Wendelschafer-Crabb G, Johnson T, Hazen E, Kennedy WR (1999) Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation. Pain 81:135–145PubMedCrossRefGoogle Scholar
  7. 7.
    Wiadrowski TP, Marshman G (2001) Subcutaneous fat necrosis of the newborn following hypothermia and complicated by pain and hypercalcaemia. Australas J Dermatol 42:207–210PubMedCrossRefGoogle Scholar
  8. 8.
    Diamantis S, Bastek T, Groben P, Morrell D (2006) Subcutaneous fat necrosis in a newborn following icebag application for treatment of supraventricular tachycardia. J Perinatol 26:518–520PubMedCrossRefGoogle Scholar
  9. 9.
    Taylor CA (1949) Survival of rat skin and changes in hair pigmentation following freezing. J Exp Zool 110:77–111PubMedCrossRefGoogle Scholar
  10. 10.
    Shurtleff D, Gilliatt RW, Thomas JR, Pezeshkpour GH (1993) An assessment of peripheral nerve damage in the rat following nonfreezing cold exposure: an electrophysiological and histopathologic examination. Technical report, Jan 1991–Jan 1992. Naval Medical Research Institute: Bethesda, MD. http://stinet.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=ADA264293
  11. 11.
    Irwin MS (1996) Nature and mechanism of peripheral nerve damage in an experimental model of nonfreezing cold injury. Ann R Coll Surg Engl 78:372–379PubMedGoogle Scholar
  12. 12.
    Irwin MS, Sanders R, Green CJ, Terenghi G (1997) Neuropathy in nonfreezing cold injury (trench foot). J R Soc Med 90:433–438PubMedGoogle Scholar
  13. 13.
    Jia J, Pollock M, Jia J (1998) Cold injury to nerves is not due to ischaemia alone. Brain 21:989–1001CrossRefGoogle Scholar
  14. 14.
    Iida H, Schmelzer JD, Schmeichel AM, Wang Y, Low PA (2003) Peripheral nerve ischemia: reperfusion injury and fiber regeneration. Exp Neurol 184:997–1002PubMedCrossRefGoogle Scholar
  15. 15.
    Saray A, Can B, Akbiyik F, Askar I (1999) Ischaemia-reperfusion injury of the peripheral nerve: an experimental study. Microsurgery 19:374–380PubMedCrossRefGoogle Scholar
  16. 16.
    Schmelzer JD, Zochodne DW, Low PA (1989) Ischemic and reperfusion injury of rat peripheral nerve. Proc Natl Acad Sci U S A 86:1639–1642PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2009

Authors and Affiliations

  • Sydney R. Coleman
    • 1
  • Kulveen Sachdeva
    • 2
  • Barbara M. Egbert
    • 3
  • Jessica Preciado
    • 4
  • John Allison
    • 4
  1. 1.Department of SurgeryNYU School of MedicineNew YorkUSA
  2. 2.San Ramon Regional Medical CenterSan RamonUSA
  3. 3.Department of Dermatology and PathologyStanford University Medical CenterPalo AltoUSA
  4. 4.Zeltiq AestheticsPleasantonUSA

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