Aesthetic Plastic Surgery

, Volume 33, Issue 3, pp 336–339 | Cite as

Use of Tissue Sealants in Face-Lifts: A Metaanalysis

  • Yong-Chen PorEmail author
  • Luming Shi
  • Miny Samuel
  • Colin Song
  • Vincent Kok-Leng Yeow
Original Article



This review sought to determine the efficacy of tissue sealants such as fibrin tissue adhesives and platelet-rich plasma in reducing postoperative drainage, ecchymosis, and edema after face-lift surgery.


The electronic databases MEDLINE (1966–May 2007) and EMBASE (1974–May 2007) and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched for human studies, randomized controlled trials, controlled clinical trials, metaanalyses, and reviews of randomized controlled trials using the key words “fibrin tissue adhesive,” “tissue sealant,” “platelet-rich plasma,” “face-lift,” “rhytidoplasty,” “rhytidectomy,” and “facial plastic surgery.” The search yielded 10 articles, only 3 of which met our inclusion criteria. The three studies were within-patient comparisons (patients acted as their own controls).


Although not statistically significant, the pooled results showed a strong trend toward reduction in postoperative drainage at 24 h and ecchymosis with the use of tissue sealants compared with the control arm of the study. No difference in outcomes was observed between the tissue sealant and control arms of the study in terms of postoperative edema measurement.


There was no statistically significant benefit from the use of tissue sealants in face-lift surgery. However, tissue sealants may be useful for patients at a high risk for hematoma and ecchymosis formation.


Face-lift Metaanalysis Rhytidoplasty Tissue sealant 


  1. 1.
    Jones BM, Grover R (2004) Avoiding hematoma in cervicofacial rhytidectomy: a personal 8-year quest. Reviewing 910 patients. Plast Reconstr Surg 113:381–387PubMedCrossRefGoogle Scholar
  2. 2.
    Mobley SR, Hilinski J, Toriumi DM (2002) Surgical tissue adhesives. Facial Plast Surg Clin North Am 10:47–154CrossRefGoogle Scholar
  3. 3.
    Eppley BL, Woodell JE, Higgins J (2004) Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 114:1502–1508PubMedCrossRefGoogle Scholar
  4. 4.
    Marchac D, Greensmith AL (2005) Early postoperative efficacy of fibrin glue in face lifts: a prospective randomized trial. Plast Reconstr Surg 115:911–916PubMedCrossRefGoogle Scholar
  5. 5.
    Oliver DW, Hamilton SA, Figle AA, Wood SH, Lamberty BG (2001) A prospective, randomized, double-blind trial of the use of fibrin sealant for face-lifts. Plast Reconstr Surg 108:2101–2105PubMedCrossRefGoogle Scholar
  6. 6.
    Powell DM, Chang E, Farrior EH (2001) Recovery from deep-plane rhytidectomy following unilateral wound treatment with autologous platelet gel: a pilot study. Arch Facial Plast Surg 3:245–250PubMedCrossRefGoogle Scholar
  7. 7.
    Sanchez AR, Sheridan PJ, Kupp LI (2003) Is platelet-rich plasma the perfect enhancement factor? A current review. Int J Oral Maxillofac Implants 18:93–103PubMedGoogle Scholar
  8. 8.
    Jones BM, Grover R, Hamilton S (2007) The efficacy of surgical drainage in cervicofacial rhytidectomy: a prospective randomized, controlled trial. Plast Reconstr Surg 120:263–270PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2008

Authors and Affiliations

  • Yong-Chen Por
    • 1
    Email author
  • Luming Shi
    • 2
  • Miny Samuel
    • 2
  • Colin Song
    • 3
  • Vincent Kok-Leng Yeow
    • 1
  1. 1.Department of Plastic, Reconstructive and Aesthetic SurgeryKandang Kerbau Women’s and Children’s HospitalSingaporeSingapore
  2. 2.Clinical Trials and Epidemiology Research UnitNational Medical Research Council, Ministry of HealthSingaporeSingapore
  3. 3.Department of Plastic, Reconstructive and Aesthetic SurgerySingapore General HospitalSingaporeSingapore

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