Aesthetic Plastic Surgery

, Volume 32, Issue 3, pp 465–469

Fat Injection for Cases of Severe Burn Outcomes: A New Perspective of Scar Remodeling and Reduction

Original Article

DOI: 10.1007/s00266-008-9122-1

Cite this article as:
Klinger, M., Marazzi, M., Vigo, D. et al. Aesth Plast Surg (2008) 32: 465. doi:10.1007/s00266-008-9122-1



Despite civilization and progress, burns occur frequently in the world. Remarkable discoveries of wound healing mechanisms have been reported. On the other hand, long-term outcomes from burn injuries represent a barrier to improvement of patients’ social, functional, and psychological condition. Lipofilling, described since the 1980s, currently is used for several clinical applications. This study aimed to verify whether lipofilling could ameliorate scar remodeling in three clinical cases.


Three adult patients with hemifacial hypertrophic scars and keloids resulting from severe burns 2 to 13 years previously were selected. The patients were treated by injection of adipose tissue harvested from abdominal subcutaneous fat and processed according to Coleman’s technique. Two injections (with a 13-month interval between) were administered at the dermohypodermal junction. Histologic examination of scar tissue punch biopsies (hematoxylin-eosin staining) before and after the treatment was performed as well as magnetic resonance scan with contrast.


The clinical appearance and subjective patient feelings after a 6-month follow-up period suggest considerable improvement in the mimic features, skin texture, and thickness. Histologic examination shows patterns of new collagen deposition, local hypervascularity, and dermal hyperplasia in the context of new tissue, with high correspondence to the original.


The preliminary results show that lipofilling improves scar quality and suggest a tissue regeneration enhancing process.


Adipose cell Burn Liposuction Scar Stem cell 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Università degli Studi di Milano, Istituto di Chirurgia PlasticaUnità Operativa di Chirurgia Plastica, IRCCS Istituto Clinico HumanitasRozzanoItaly
  2. 2.Centro di Riferimento Regionale Colture CellulariOspedale Niguarda “Ca’ Granda”MilanoItaly
  3. 3.Dipartimento di Scienze e Tecnologie Veterinarie per la Sicurezza AlimentareUniversità degli Studi di MilanoMilanoItaly
  4. 4.Dipartimento di Chimica FarmaceuticaUniversità degli Studi di PaviaPaviaItaly

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