Aesthetic Plastic Surgery

, Volume 32, Issue 1, pp 155–158 | Cite as

Autologous Platelet-Rich Plasma as an Adipocyte In Vivo Delivery System: Case Report

  • Bruno Azzena
  • Francesco Mazzoleni
  • Giovanni Abatangelo
  • Barbara Zavan
  • Vincenzo Vindigni
Original Article


Tissue engineering has emerged as a promising alternative to current clinical treatments for restoration of soft tissue defects. A key element in the process of tissue engineering is an ideal implant that provides structural support and a favorable environment for growing cells. The authors hypothesized that autologous platelet-rich plasma (APRP) could be used as an in vivo adipocyte delivery system to favor cell survival and to stimulate early recruitment of microcapillaries to the site of implantation. Autologous fat was included in APRP and injected as a gel into a subcutaneous pocket created to correct a painful, adherent scar at the shoulder level in a 75-year-old woman. The surgical outcome was evaluated by histologic and immunohistochemical analysis as well as by ecography before and after surgery. The results were satisfactory, showing fat survival 1 year after surgery. The characteristics of this new material should stimulate research into future clinical applications for such cell constructs in plastic and reconstructive surgery.


Adipose tissue engineering Autologous platelet-rich plasma Filler Regenerative medicine 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Bruno Azzena
    • 1
  • Francesco Mazzoleni
    • 1
  • Giovanni Abatangelo
    • 2
  • Barbara Zavan
    • 2
  • Vincenzo Vindigni
    • 1
  1. 1.Unit of Plastic and Reconstructive SurgeryUniversity of PadovaPadovaItaly
  2. 2.Department of Histology, Microbiology and Medical BiotechnologyUniversity of PadovaPadovaItaly

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