Aesthetic Plastic Surgery

, Volume 31, Issue 4, pp 358–364

Influence of Rifampin on Capsule Formation Around Silicone Implants in a Rat Model

  • Ramazan Erkin Unlu
  • Asu Deniz Yilmaz
  • Hakan Orbay
  • Belgin Can
  • Ibrahim Tekdemir
  • Omer Sensoz
Article

DOI: 10.1007/s00266-006-0248-8

Cite this article as:
Unlu, R.E., Yilmaz, A.D., Orbay, H. et al. Aesth Plast Surg (2007) 31: 358. doi:10.1007/s00266-006-0248-8

Abstract

This study investigated the effect of rifampin on the thickness of capsules around silicone implants by bactericidal activity against Stapylococcus epidermidis. Silicone blocks (1 × 1 cm) were placed into pockets created for each of the 40 rats included in the study. In group 1, the operation was performed under aseptic conditions. In group 2, standard S. epidermidis was inoculated into the pocket, whereas rifampin and S. epidermidis were applied in group 3. In group 4, only rifampin was applied topically on implants. After 12 weeks, the peri-implant capsules were removed and examined under a photomicroscope and a scanning electron microscope. The mean thickness of the capsules was 63.307 μm in group 1, 111.538 μm in group 2, 43.076 μm in group 3, and 30.384 μm in group 4. The differences between groups 2 and 3 and groups 2 and 4 were found to be statistically significant (p < 0.001). Rifampin appears to be an agent for preventing peri-implant capsule formation.

Keywords

Peri-implant capsule formation Rifampin Silicone implants Stapylococcus epidermidis 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Ramazan Erkin Unlu
    • 1
  • Asu Deniz Yilmaz
    • 1
    • 4
  • Hakan Orbay
    • 1
  • Belgin Can
    • 2
  • Ibrahim Tekdemir
    • 3
  • Omer Sensoz
    • 1
  1. 1.Department of 2nd Plastic and Reconstructive SurgeryAnkara Numune Training and Research HospitalAnkaraTurkey
  2. 2.Department of Histology and EmbryologyAnkara University Faculty of MedicineAnkaraTurkey
  3. 3.Department of AnatomyAnkara University Faculty of MedicineAnkaraTurkey
  4. 4.AnkaraTurkey

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