Aesthetic Plastic Surgery

, Volume 29, Issue 2, pp 102–106 | Cite as

Complications Associated With Isotretinoin Use After Rhinoplasty

Case Reports

Abstract

Background

This study aimed to evaluate the association between the postoperative use of isotretinoin and the formation of nasal tip deformities after rhinoplasty.

Methods

A retrospective study investigated a case series of patients who presented with nasal tip deformities subsequent to the use of isotretinoin after rhinoplasty. Patients who had taken isotretinoin after rhinoplasty were identified from a single surgeon’s case log. Clinic charts and operative reports were reviewed. Predisposing factors and time intervals to complications were identified.

Results

Three patients were found to have undergone isotretinoin therapy after rhinoplasty. Nasal tip deformities included bossa formation, asymmetry, and prominence of a composite graft. All three patients required subsequent procedures to repair soft tissue nasal tip deformities. In all three cases, isotretinoin was started within 2 years of the primary rhinoplasty. The nasal tip deformities were first observed within 6 months after isotretinoin was started.

Conclusions

Three cases are described in which postoperative use of isotretinoin was associated with nasal tip deformities after rhinoplasty. Further studies are needed to investigate this possible causative relationship and to describe the risks involved.

Keywords

Complications Isotretinoin Nasal tip bossae Rhinoplasty 

References

  1. 1.
    Bauer, EA, Seltzer, JL, Eisen, AZ 1982Inhibition of collagen degradative enzymes by retinoic acid in vitroJ Am Acad Dermatol6603607PubMedGoogle Scholar
  2. 2.
    Gillman, GS, Simons, RL, Lee, DJ 1999Nasal tip bossae in rhinoplasty: Etiology, predisposing factors, and management techniquesArch Facial Plast Surg18389PubMedGoogle Scholar
  3. 3.
    Goodwin, WJ,Jr, Schmidt, JF 1987Iatrogenic nasal tip bossae: Etiology, prevention, and treatmentArch Otolaryngol Head Neck Surg113737739PubMedGoogle Scholar
  4. 4.
    Gryskiewicz, JM, Rohrich, RJ, Reagan, BJ, Schwartz, BM 2001The use of Alloderm for the correction of nasal contour deformitiesPlast Reconstr Surg107571PubMedGoogle Scholar
  5. 5.
    Kridel, RW, Yoon, PJ, Koch, RJ 2003Prevention and correction of nasal tip bossae in rhinoplastyArch Facial Plast Surg5416422PubMedGoogle Scholar
  6. 6.
    Ratner, D, Tse, Y, Marchell, N, Goldman, MP, Fitzpatrick, RE, Fader, DJ 1999Cutaneous laser resurfacingJ Am Acad Dermatol41365389PubMedGoogle Scholar
  7. 7.
    Wysowski, DK, Swann, J, Vega, A 2002Use of isotretinoin (Accutane) in the United States: Rapid increase from 1992 through 2000J Am Acad Dermatol46505509PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Department of Otolaryngology and Communication SciencesMedical College of WisconsinMilwaukeeUSA

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