Is ceramics an appropriate bone morphogenetic protein delivery system for clinical use?

  • Slobodan VukicevicEmail author
  • Nikola Stokovic
  • Marko Pecina
Letter to the Editor


Compliance with ethical standards

Conflict of interest

MP and NS declare no conflict of interest. SV is the founder of Genera Research, a Croatian biotechnology company conducting clinical trials with Osteogrow, a novel bone graft substitute.


  1. 1.
    Kuroiwa Y, Niikura T, Lee SY, Oe K, Iwakura T, Fukui T, Matsumoto T, Matsushita T, Nishida K, Kuroda R (2018) Escherichia coli-derived BMP-2-absorbed β-TCP granules induce bone regeneration in rabbit critical-sized femoral segmental defects. Int Orthop.
  2. 2.
    Vukicevic S, Oppermann H, Verbanac D, Jankolija M, Popek I, Curak J, Brkljacic J, Pauk M, Erjavec I, Francetic I, Dumic-Cule I, Jelic M, Durdevic D, Vlahovic T, Novak R, Kufner V, Bordukalo Niksic T, Kozlovic M, Banic Tomisic Z, Bubic-Spoljar J, Bastalic I, Vikic-Topic S, Peric M, Pecina M, Grgurevic L (2014) The clinical use of bone morphogenetic proteins (BMPs) revisited: a novel BMP6 biocompatible carrier device OSTEOGROW for bone healing. Int Orthop 38:635–647CrossRefGoogle Scholar
  3. 3.
    Grgurevic L, Pecin M, Erjavec I, Capag H, Pauk M, Kufner V, Lipar M, Bubic Spoljar J, Bordukalo-Niksic T, Maticic D, Oppermann H, Peric M, Sampath TK, Vukicevic S (2018) Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits. J Bone Miner Res Plus.
  4. 4.
    Manrique E, Chaparro D, Cebrián JL, López-Durán L (2014) In vivo tricalcium phosphate, bone morphogenetic protein and autologous bone marrow biomechanical enhancement in vertebral fractures in a porcine model. Int Orthop 38:1993–1999CrossRefGoogle Scholar
  5. 5.
    Bilic R, Simic P, Jelic M, Stern-Padovan R, Dodig D, van Meerdervoort HP, Martinovic S, Ivankovic D, Pecina M, Vukicevic S (2006) Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis. Int Orthop 30:128–134CrossRefGoogle Scholar
  6. 6.
    Reichert JC, Wullschleger ME, Cipitria A, Lienau J, Cheng TK, Schütz MA, Duda GN, Nöth U, Eulert J, Hutmacher DW (2011) Custom-made composite scaffolds for segmental defect repair in long bones. Int Orthop 35:1229–1236CrossRefGoogle Scholar
  7. 7.
    Lissenberg-Thunnissen SN, de Gorter DJ, Sier CF, Schipper IB (2011) Use and efficacy of bone morphogenetic proteins in fracture healing. Int Orthop 35:1271–1280CrossRefGoogle Scholar
  8. 8.
    Dumic-Cule I, Pecina M, Jelic M, Jankolija M, Popek I, Grgurevic L, Vukicevic S (2015) Biological aspects of segmental bone defects management. Int Orthop 39:1005–1011CrossRefGoogle Scholar
  9. 9.
    Vukicevic S, Grgurevic L, Pecina M (2017) Clinical need for bone morphogenetic proteins. Int Orthop 41:2415–2416CrossRefGoogle Scholar
  10. 10.
    Dumic-Cule I, Peric M, Kucko L, Grgurevic L, Pecina M, Vukicevic S (2018) Bone morphogenetic proteins in fracture repair. Int Orthop 42:2619–2626CrossRefGoogle Scholar
  11. 11.
    Keskin DS, Tezcaner A, Korkusuz F, Hasirci V (2005) Collagen-chondroitin sulfate-based PLLA-SAIB-coated rhBMP-2 delivery system for bone repair. Biomaterials 26:4023–4034CrossRefGoogle Scholar
  12. 12.
    Das SP, Ganesh S, Pradhan S, Singh D, Mohanty RN (2014) Effectiveness of recombinant human bone morphogenetic protein-7 in the management of congenital pseudoarthrosis of the tibia: a randomised controlled trial. Int Orthop 38:1987–1992CrossRefGoogle Scholar

Copyright information

© SICOT aisbl 2019

Authors and Affiliations

  1. 1.Laboratory for Mineralized Tissues, Center of Excellence for Reproductive and Regenerative Medicine, Centre for Translational and Clinical ResearchUniversity of Zagreb School of MedicineZagrebCroatia
  2. 2.Department of Orthopaedic SurgerySchool of Medicine University of ZagrebZagrebCroatia

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