The effect of anticoagulants on venous thrombosis prevention after knee arthroscopy: a systematic review
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Knee arthroscopy, with its unique advantages, has become a routine surgery and is widely carried out around the world. Venous thromboembolism (VTE) after knee arthroscopy is a potentially serious complication. This article analyzes the effects of anticoagulant therapy after knee arthroscopy.
We used key words or entry terms without any limitations to search the PubMed, Embase, and Cochrane Library databases. Randomized controlled trials (RCTs) of drug prophylaxis for VTE after knee arthroscopy until November 2017 were included in our review.
This systematic review identified nine RCTs, consisting of 4290 patients, investigating drug prophylaxis in knee arthroscopy. There are three main drugs for preventing thrombosis after arthroscopic knee surgery: low-molecular-weight heparin (LMWH), rivaroxaban, and aspirin. Our study concluded that there is no difference in symptomatic VTE (excluding symptomatic distal DVT) risk during anticoagulant prophylaxis (RR, 0.98; 95% CI, 0.44–2.19; I2 value = 0%; P = 0.97). Moreover, there was a lower incidence of symptomatic distal DVT (RR, 0.16; 95% CI, 0.06–0.45; I2 value = 0%; P = 0.0005) in the anticoagulant group than in the control group.
In our study, anticoagulant therapy after knee arthroscopy was ineffective. We recommend that anticoagulants not be provided routinely after knee arthroscopy.
KeywordsVenous thromboembolism Anticoagulant Knee arthroscopy
Conceived and designed the article: XBT and QX. Literature search and data extraction: HFH, YKS, and XTY. Analyzed the data: HFH and SSL. Wrote the paper: HFH, JLT, and LS. All of the authors read and approved the final manuscript.
This work was supported by grants from the National Natural Science Foundation of China (No. 81560356, No. 61264004), the Science Foundation of Guizhou Province (No. (2015) 3044), the Science and Technology Foundation of Guizhou Province (No. (2015) 2089, No. gzwjkj2018-1-040), and High-level Creative Talent Training Program in Guizhou Province of China (Grant No. 4015).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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