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International Orthopaedics

, Volume 42, Issue 12, pp 2941–2948 | Cite as

Risk factors for metastasis at presentation with conventional chondrosarcoma: a population-based study

  • Kehan Song
  • Xiao Shi
  • Xin Liang
  • Hongli Wang
  • Fei Zou
  • Feizhou Lu
  • Xiaosheng Ma
  • Jianyuan Jiang
Original Paper
  • 110 Downloads

Abstract

Purpose

The aim of the study was to investigate risk factors for metastasis at diagnosis.

Methods

We collected patients diagnosed with conventional chondrosarcoma between 1983 and 2014 from the Surveillance, Epidemiology, and End Results (SEER) database. Each patient was classified as having metastatic or localized disease. Univariate and multivariate logistic regression analyses were applied to determine which characteristics were risk factors for metastasis at diagnosis.

Results

Two thousand three hundred forty-nine patients were collected and 180 patients had metastasis at presentation. Data on age, gender, primary site, grade, and tumour size were enrolled into the multivariate logistic analysis. Greater age (60 years or older: OR = 1.872, 95% CI, 1.206 to 2.904), axial or craniofacial location (spine: OR = 1.775, 95% CI, 1.188 to 2.651; thoracic cage: OR = 2.034, 95% CI, 1.321 to 3.134; craniofacial bones: OR = 5.507, 95% CI, 3.001 to 10.107), higher grade (grade II: OR = 1.849, 95%CI, 1.181 to 2.895; grade III: OR = 4.016, 95%CI, 2.513 to 6.418), and larger tumour size (size over 10 cm: OR = 7.135, 95%CI, 2.130 to 23.893) were associated with an increased risk of metastasis at presentation.

Conclusions

Conventional chondrosarcoma patients with greater age, axial or craniofacial tumour location, higher grade, and larger tumor size were more likely to have metastasis at diagnosis.

Keywords

Bone cancer Conventional chondrosarcoma Risk factor Metastasis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Because we obtain data from the SEER database with open access, we did not need to acquire patient consent or ethical review committee statement, but we were required to sign a Data-Use Agreement for the SEER 1973–2014 Research Data File to gain access to the SEER database.

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Copyright information

© SICOT aisbl 2018

Authors and Affiliations

  • Kehan Song
    • 1
  • Xiao Shi
    • 2
  • Xin Liang
    • 3
  • Hongli Wang
    • 1
  • Fei Zou
    • 1
  • Feizhou Lu
    • 1
  • Xiaosheng Ma
    • 1
  • Jianyuan Jiang
    • 1
  1. 1.Department of Orthopaedics, Huashan HospitalFudan UniversityShanghaiChina
  2. 2.Department of Oncology, Shanghai Medical CollegeFudan UniversityShanghaiChina
  3. 3.Department of Ophthalmology, Shanghai Medical CollegeFudan UniversityShanghaiChina

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