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International Orthopaedics

, Volume 41, Issue 10, pp 2067–2074 | Cite as

Effects of low-intensity pulsed ultrasound on soft tissue micro-circulation in the foot

  • Anna Katharina Kösters
  • Bergita Ganse
  • Boyko Gueorguiev
  • Kajetan Klos
  • Ali Modabber
  • Sven Nebelung
  • Bong-Sung S. Kim
  • Matthias Knobe
Original Paper

Abstract

Purpose

Low-intensity pulsed ultrasound (LIPUS) has been shown to accelerate bone healing and is considered to increase blood flow. The aim of this study was to assess changes in micro-circulation of the foots’ soft tissue in response to LIPUS intervention. We hypothesised improved micro-circulation in response to LIPUS.

Methods

Micro-circulation was assessed in 2 mm and 8 mm-deep skin of 50 healthy volunteers using non-invasive laser-doppler spectrophotometry (O2C-device). Measurements were performed before LIPUS-intervention (pre), directly after intervention (post) and 20, 40 and 60 minutes after LIPUS.

Results

All parameter of micro-circulation increased directly after LIPUS intervention at 8 mm depth. Participants with a low pre-intervention flow showed the largest changes (p < 0.001) with an increased post-flow of 38%. SO2 levels increased significantly after intervention (p = 0.045) and decreased after 60 minutes in comparison to pre-intervention status. rHb levels after 60 min were significantly higher in comparison to pre-intervention levels.

Conclusion

In healthy volunteers, low-intensity pulsed ultrasound led to significant short-term changes in microcirculation of the foot. Younger subjects with a low pre-flow level and smokers showed a higher potential to increase blood flow after LIPUS.

Keywords

Low-intensity pulsed ultrasound O2C Micro-circulation Blood flow Soft tissue Hindfoot 

Notes

Acknowledgments

We would like to thank Daniel Timo Behrens for his consultation.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Funding

None.

Ethical approval

Ethics committee of the RWTH Aachen University Hospital, ethics approval EK 346/14.

Informed consent

Each author certifies that his or her institution approved the human protocol for this investigation, that all investigations were conducted in conformity with the ethical principles of research, and that informed consent for participation in the study was obtained.

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Copyright information

© SICOT aisbl 2017

Authors and Affiliations

  1. 1.Department of Orthopaedic TraumaUniversity of Aachen Medical CenterAachenGermany
  2. 2.AO Research Institute DavosDavosSwitzerland
  3. 3.Department of Foot and Ankle SurgeryCatholic Hospital MainzMainzGermany
  4. 4.Department of Oral and Maxillofacial SurgeryUniversity of Aachen Medical CenterAachenGermany
  5. 5.Department of RadiologyUniversity of Aachen Medical CenterAachenGermany
  6. 6.Department of Plastic Surgery, Reconstructive and Hand SurgeryUniversity of Aachen Medical CenterAachenGermany

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