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International Orthopaedics

, Volume 37, Issue 6, pp 1165–1170 | Cite as

Pigmented villonodular synovitis: a retrospective study of seventy five cases (eighty one joints)

  • Xiaomei MaEmail author
  • Guodong Shi
  • Chunyan Xia
  • Huimin Liu
  • Jin He
  • Wentao Jin
Original Paper

Abstract

Purpose

Pigmented villonodular synovitis (PVNS) is a relatively rare, benign proliferation lesion of the synovium of large joints, but there is not much information available about the disease’s aetiology, clinical history, differential diagnosis, treatment, and long-term effects. We conducted a study to analyse these aspects of PVNS.

Methods

We reviewed all clinical data for 75 patients with PVNS (81 joints) who were treated either by synovectomy alone or synovectomy plus arthroplasty.

Results

In all cases, the diagnosis of PVNS was confirmed by pathological examination. The ratio of males to females was 27:48, and the average age of patients was 46 years (range, 15–80 years). Lesions were located in the knee, hip, or ankle, and pain and swelling were the main symptoms. Of 75 patients, 42 had a history of trauma to the involved joint. Forty-one patients (43 joints) underwent synovectomy alone, and 34 patients (38 joints) underwent synovectomy and arthroplasty together. Of the 75 patients, 61 had full follow-up data. Twelve patients had recurrent legions detected by pathological examinations; four patients had more than two recurrences. Moreover, five patients developed PVNS after arthroplasty.

Conclusions

PVNS occurs most often in middle-aged women and most frequently involves the knee, followed by the hip and ankle. The disease’s etiology is varied and unclear. Surgical excision alone or with arthroplasty is an effective treatment, but there is a high rate of recurrence.

Keywords

Magnetic Resonance Imaging Chronic Myeloid Leukemia Bone Erosion Pigment Villonodular Synovitis Arthroscopic Synovectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Medical editor Katharine O’Moore-Klopf, ELS (East Setauket, NY, USA) provided professional English-language editing of this article.

Conflict of interest

Each author certifies that he or she has no commercial associations (e.g., consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Xiaomei Ma
    • 1
    Email author
  • Guodong Shi
    • 2
  • Chunyan Xia
    • 1
  • Huimin Liu
    • 1
  • Jin He
    • 1
  • Wentao Jin
    • 3
  1. 1.Department of Pathology, Changzheng HospitalSecond Military Medical UniversityShanghaiChina
  2. 2.Department of Osteology, Changzheng HospitalSecond Military Medical UniversityShanghaiChina
  3. 3.Department of Radiology, Changzheng HospitalSecond Military Medical UniversityShanghaiChina

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