International Orthopaedics

, Volume 35, Issue 9, pp 1349–1358 | Cite as

Percutaneous vertebroplasty versus balloon kyphoplasty for treatment of osteoporotic vertebral compression fracture: a meta-analysis of randomised and non-randomised controlled trials

  • Shiliang Han
  • Shuanglin Wan
  • Lei Ning
  • Yongjun Tong
  • Jianfeng Zhang
  • Shunwu Fan



There is still debate over whether vertebroplasty (VP) or kyphoplasty (KP) is superior for the treatment of osteoporosis vertebral compression fractures (VCFs). We performed a systematic review and meta-analysis of randomised and non-randomised controlled trials comparing VP with KP to reach a relatively conclusive answer.


We searched computerised databases comparing efficacy and safety of VP and KP in osteoporotic fractures. These trials reported pain relief (Visual Analogue Scale), disability (Oswestry disability score) and complications (i.e., cement leakage, incident fractures) as the primary outcome.


Eight studies involving 848 patients were identified. The outcome showed that VP is more effective in the short-term (no more than seven days) pain relief. Kyphoplasty had a superior capability for intermediate-term (around three months) functional improvement. As for long-term pain relief and functional improvement, there is no significant difference between these two interventions. Consistently, both interventions have similar risk for subsequent fracture and cement leakage.


Thus considering the higher cost of the KP procedure, we recommend VP over KP for the treatment of osteoporotic VCFs.


Weighted Mean Difference Vertebral Compression Fracture Subsequent Fracture Visual Analogue Scale Pain Score Cement Leakage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Vertebral compression fractures






Randomised controlled trials


Non-randomised controlled trials


Clinical controlled trials


Visual analog scale


Oswestry disability score


Relative risks


Weighted mean difference



The intent of this statement is to display our idea on osteoporotic vertebral compression fracture. All the authors state that there are no outside grants in support of this research this work. There is no financial and personal relationships with other people or organisations that could inappropriately influence (bias) our work.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Shiliang Han
    • 1
  • Shuanglin Wan
    • 1
  • Lei Ning
    • 1
  • Yongjun Tong
    • 1
  • Jianfeng Zhang
    • 1
  • Shunwu Fan
    • 1
  1. 1.Department of Orthopaedics, Sir Run Run Shaw HospitalSchool of Medicine, Zhejiang UniversityZhejiangChina

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