International Orthopaedics

, Volume 35, Issue 7, pp 1049–1056 | Cite as

Low-grade chondrosarcoma of bone: experiences from the Vienna Bone and Soft Tissue Tumour Registry

  • Philipp T. FunovicsEmail author
  • Joannis Panotopoulos
  • Manuel Sabeti-Aschraf
  • Farshid Abdolvahab
  • Josef M. Funovics
  • Susanna Lang
  • Rainer I. Kotz
  • Martin Dominkus
Original Paper


In a retrospective single-centre study, 70 low-grade chondrosarcoma (LCS) (31 female/39 male patients with a mean age of 40 years) were reviewed to evaluate surgical management. The mean overall follow-up was 81 months (median: 73 months, range: 6–317 months). Seventeen lesions (24.3%) in the trunk and 53 (75.7%) in the extremities were treated by curettage (48.6%) or resection (51.5%). Local recurrence occurred in eight patients (11.4%) 18 months postoperatively (median: 18 months, range: 0–41 months). Recurrence-free survival was significantly better for patients with extremity lesions compared to truncal lesions, but was not affected by resection margin. The anatomical site “trunk” and an “intralesional” resection margin had a significant independent prognostic influence in multivariate analysis. Curettage with local adjuvants is a viable treatment option for most extremity LCS. In truncal LCS wide resection is recommended despite a potentially higher complication rate.


Local Recurrence Resection Margin Anatomical Site Chondrosarcoma Wide Resection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors have no disclosures to make.


  1. 1.
    Dahlin DC, Henderson ED (1956) Chondrosarcoma, a surgical and pathological problem; review of 212 cases. J Bone Joint Surg Am 38:1025–1038PubMedGoogle Scholar
  2. 2.
    Rosenthal DI, Schiller AL, Mankin HJ (1984) Chondrosarcoma: correlation of radiological and histological grade. Radiology 150(1):21–26PubMedGoogle Scholar
  3. 3.
    Lee F, Mankin HJ, Fondren G et al (1999) Chondrosarcoma of bone: an assessment of outcome. J Bone Joint Surg Am 81:326–338PubMedCrossRefGoogle Scholar
  4. 4.
    Eriksson AI, Schiller A, Mankin HJ (1980) The management of chondrosarcoma of bone. Clin Orthop Relat Res 153:44–66PubMedGoogle Scholar
  5. 5.
    Björnsson J, McLeod RA, Unni KK et al (1998) Primary chondrosarcoma of long bones and limb girdles. Cancer 83:2105–2119PubMedCrossRefGoogle Scholar
  6. 6.
    Donati D, Ghoneimy AEL, Bertoni F et al (2005) Surgical treatment and outcome of conventional pelvic chondrosarcoma. J Bone Joint Surg Br 87:1527–1530PubMedCrossRefGoogle Scholar
  7. 7.
    Streitbürger A, Ahrens H, Balke M et al (2009) Grade I chondrosarcoma of bone: the Münster experience. J Cancer Res Clin Oncol 135(4):543–550PubMedCrossRefGoogle Scholar
  8. 8.
    Rizzo M, Ghert MA, Harrelson JM et al (2001) Chondrosarcoma of bone: analysis of 108 cases and evaluation for predictors of outcome. Clin Orthop Relat Res 391:224–233PubMedCrossRefGoogle Scholar
  9. 9.
    Kreicbergs A, Boquist I, Borssén B et al (1982) Prognostic factors in chondrosarcoma: a comparative study of cellular DNA content and clinicopathologic features. Cancer 50:577–583PubMedCrossRefGoogle Scholar
  10. 10.
    Sheth DS, Yasko AW, Johnson ME et al (1996) Chondrosarcoma of the pelvis. Prognostic factors for 67 patients treated with definitive surgery. Cancer 78(4):745–750PubMedCrossRefGoogle Scholar
  11. 11.
    Fiorenza F, Abudu A, Grimer RJ et al (2002) Risk factors for survival and local control in chondrosarcoma of bone. J Bone Joint Surg Br 84:93–94PubMedCrossRefGoogle Scholar
  12. 12.
    Bauer HC, Brosjö O, Kreicbergs A et al (1995) Low risk of recurrence of enchondroma and low-grade chondrosarcoma in extremities. 80 patients followed for 2–25 years. Acta Orthop Scand 66(3):283–288PubMedCrossRefGoogle Scholar
  13. 13.
    Okada K, Nagasawa H, Chida S et al (2009) Curettage with pasteurization in situ for grade 1 chondrosarcoma—long-term follow up study of less invasive surgical procedure. Med Sci Monit 15(3):CS44–CS48PubMedGoogle Scholar
  14. 14.
    Ahlmann ER, Menendez LR, Fedenko AN et al (2006) Influence of cryosurgery on treatment outcome of low-grade chondrosarcoma. Clin Orthop Relat Res 451:201–207PubMedCrossRefGoogle Scholar
  15. 15.
    Etchebehere M, de Camargo OP, Croci AT et al (2005) Relationship between surgical procedure and outcome for patients with grade I chondrosarcomas. Clinics (Sao Paulo) 60(2):121–126Google Scholar
  16. 16.
    Donati D, Colangeli S, Colangeli M et al (2010) Surgical treatment of grade I central chondrosarcoma. Clin Orthop Relat Res 468(2):581–589PubMedCrossRefGoogle Scholar
  17. 17.
    Hanna SA, Whittingham-Jones P, Sewell MD et al (2009) Outcome of intralesional curettage for low-grade chondrosarcoma of long bones. Eur J Surg Oncol 35(12):1343–1347PubMedGoogle Scholar
  18. 18.
    Aarons C, Potter BK, Adams SC et al (2009) Extended intralesional treatment versus resection of low-grade chondrosarcomas. Clin Orthop Relat Res 467(8):2105–2111PubMedCrossRefGoogle Scholar
  19. 19.
    Leerapun T, Hugate RR, Inwards CY et al (2007) Surgical management of conventional grade I chondrosarcoma of long bones. Clin Orthop Relat Res 463:166–172PubMedGoogle Scholar
  20. 20.
    Ozaki T, Lindner N, Hillmann A et al (1996) Influence of intralesional surgery on treatment outcome of chondrosarcoma. Cancer 77:1292–1297PubMedCrossRefGoogle Scholar
  21. 21.
    Sanerkin NG, Gallagher P (1979) A review of the behaviour of chondrosarcoma of bone. J Bone Joint Surg Br 61:395–400PubMedGoogle Scholar
  22. 22.
    Bergh P, Gunterberg B, Meis-Kindblom J et al (2001) Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas: a center-based study of 69 cases. Cancer 91(7):1201–1212PubMedCrossRefGoogle Scholar
  23. 23.
    Schwab JH, Wenger D, Unni K et al (2007) Does local recurrence impact survival in low-grade chondrosarcoma of the long bones? Clin Orthop Relat Res 462:175–180PubMedCrossRefGoogle Scholar
  24. 24.
    Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res 153:106–120PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Philipp T. Funovics
    • 1
    Email author
  • Joannis Panotopoulos
    • 1
  • Manuel Sabeti-Aschraf
    • 1
  • Farshid Abdolvahab
    • 1
  • Josef M. Funovics
    • 1
  • Susanna Lang
    • 1
  • Rainer I. Kotz
    • 1
  • Martin Dominkus
    • 1
  1. 1.Medical University of Vienna Department of Orthopaedic SurgeryVienna General HospitalViennaAustria

Personalised recommendations