International Orthopaedics

, Volume 35, Issue 6, pp 831–838

Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis

  • Liang Ning
  • Muneaki Ishijima
  • Haruka Kaneko
  • Hidetake Kurihara
  • Eri Arikawa-Hirasawa
  • Mitsuaki Kubota
  • Lizu Liu
  • Zhuo Xu
  • Ippei Futami
  • Anwarjan Yusup
  • Katsumi Miyahara
  • Shouyu Xu
  • Kazuo Kaneko
  • Hisashi Kurosawa
Original Paper

DOI: 10.1007/s00264-010-1045-1

Cite this article as:
Ning, L., Ishijima, M., Kaneko, H. et al. International Orthopaedics (SICOT) (2011) 35: 831. doi:10.1007/s00264-010-1045-1

Abstract

An enhanced expression of the inflammatory mediators in the perimeniscal synovium in knee osteoarthritis (OA) has been suggested to contribute to progressive cartilage degeneration. However, whether the expression levels of these molecules correlated with the severity of OA still remained unclear. Medial perimeniscal synovial samples were obtained from 23 patients with Kellgren-Lawrence (K/L) grades 2 to 4 of medial knee OA. Immunohistochemical analysis of the synovium revealed that the MMP-1, COX-2 and IL-1β expression of the patients with K/L 4 to be significantly reduced in comparison to those with either K/L 2 or 3, while the TGF-β expression showed the opposite. The synovial expression of MMP-1 and IL-1β showed a significant negative correlation with the severity of OA, while that of TGF-β again showed the opposite. In conclusion, although synovial inflammation remained active, the MMP-1, COX-2 and IL-1β expression in synovium decreased depending upon the severity of OA, while the TGF-β expression increased.

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Liang Ning
    • 1
  • Muneaki Ishijima
    • 1
    • 2
    • 3
  • Haruka Kaneko
    • 1
    • 2
  • Hidetake Kurihara
    • 4
  • Eri Arikawa-Hirasawa
    • 5
  • Mitsuaki Kubota
    • 2
  • Lizu Liu
    • 1
  • Zhuo Xu
    • 1
  • Ippei Futami
    • 1
    • 2
  • Anwarjan Yusup
    • 1
  • Katsumi Miyahara
    • 6
  • Shouyu Xu
    • 2
  • Kazuo Kaneko
    • 1
    • 2
    • 3
  • Hisashi Kurosawa
    • 1
    • 2
  1. 1.Department of Medicine for Motor OrganJuntendo University Graduate School of MedicineTokyoJapan
  2. 2.Department of OrthopaedicsJuntendo University School of MedicineTokyoJapan
  3. 3.Sportology CenterJuntendo University Graduate School of MedicineTokyoJapan
  4. 4.Department of Anatomy and Life StructureJuntendo University Graduate School of MedicineTokyoJapan
  5. 5.Research Institute for Diseases of Old AgesJuntendo University Graduate School of MedicineTokyoJapan
  6. 6.Division of Biomedical Imaging Research, Biomedical Research CenterJuntendo University Graduate School of MedicineTokyoJapan

Personalised recommendations