International Orthopaedics

, Volume 34, Issue 4, pp 589–597 | Cite as

The regenerative effect of platelet-rich plasma on healing in large osteochondral defects

  • Y. Sun
  • Y. Feng
  • C. Q. ZhangEmail author
  • S. B. Chen
  • X. G. Cheng
Original Paper


Platelet-rich plasma (PRP), a platelet concentrate made of autogenous blood, has been used to improve bone and soft tissue defect healing in recent years. The aim of this study was to assess the effect of PRP on articular cartilage defects in a rabbit model. Forty-eight osteochondral defects created in the femoropatellar groove were (a) left untreated, (b) treated with autogenous PRP in a poly-lactic-glycolic acid (PLGA), or (c) with PLGA alone. Platelets were enriched 5.12-fold compared to normal blood in the PRP. After four and 12 weeks, the explanted tissue specimens were assessed by macroscopic examination, micro-computed tomography, and histological evaluation. Macroscopic examination, micro-computed tomography and histology of the newly formed cartilage and bone in the defect differ significantly between the PRP-treated and the untreated groups, and stimulatory effect of PRP on osteochondral formation was observed. In conclusion, PRP in PLGA improves osteochondral healing in a rabbit model.


Subchondral Bone Cartilage Defect Osteochondral Defect Toluidine Blue Staining Articular Cartilage Defect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was supported by the Key Project Foundation of the Ministry of Health of P.R. China.

Supplementary material

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Supplementary 1 (DOC 2748 kb)
264_2009_793_MOESM2_ESM.doc (916 kb)
Supplementary 2 (DOC 916 kb)
264_2009_793_MOESM3_ESM.doc (5.1 mb)
Supplementary 3 (DOC 5194 kb)


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Y. Sun
    • 1
  • Y. Feng
    • 1
  • C. Q. Zhang
    • 1
    Email author
  • S. B. Chen
    • 1
  • X. G. Cheng
    • 1
  1. 1.Department of Orthopaedic Surgery, Shanghai Sixth People’s HospitalShanghai Jiao Tong UniversityShanghaiChina

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