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Cancer Immunology, Immunotherapy

, Volume 48, Issue 7, pp 353–362 | Cite as

Tumor-induced immune dysfunction

  • Rolf Kiessling
  • Ken Wasserman
  • Shigetoshi Horiguchi
  • Koji Kono
  • Jan Sjöberg
  • Pavel Pisa
  • Max Petersson
REVIEW

Abstract

Immune system-based approaches for the treatment of malignant disease over the past decades have often focused on cytolytic effector cells such as cytotoxic T lymphocytes (CTL), and natural killer (NK) cells. It has also been demonstrated that tumor-bearing mice can be cured using a wide variety of approaches, some of which involve cytokine-mediated enhancement of CTL and NK cell activity. However, the apparent success in mice stands in contrast to the current situation in the clinic, wherein only a minority of patients have thus far benefited from CTL- or NK cell-based antitumor approaches. The underlying causes of tumor-associated immune suppression of CTL and NK cell activity are discussed, and features of interest shared with HIV infection, leprosy, and rheumatoid arthritis are also be mentioned. Remarkable and very recent observations have shed more light upon the causes of dysfunctional alterations in CTL and NK cells often associated with these diseases, that in turn have suggested new immunotherapeutic approaches for cancer and infectious disease.

Key words Immunosuppression Cancer Tolerance Zeta chains CTL NK cells 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Rolf Kiessling
    • 1
  • Ken Wasserman
    • 2
  • Shigetoshi Horiguchi
    • 1
  • Koji Kono
    • 3
  • Jan Sjöberg
    • 4
  • Pavel Pisa
    • 1
  • Max Petersson
    • 1
  1. 1.Cancer Center Karolinska, Immune- and Genetherapy Laboratory, KS-ringen R8:01, Karolinska Hospital, S-171 76 Stockholm, Sweden e-mail: Rolf.Kiessling@mtc.ki.se; Fax: +46-8-309195SE
  2. 2.LMI, DBS, NCI-Frederick Cancer Research and Development Center, Bldg. 560, Frederick, MD 21702, USAUS
  3. 3.Yamanashi University Medical School, Department of Surgery, 1110 Shimogato, Tamaho-Cho, Nakagoma-Gun, Yamanashi-Ken, 409-38, JapanJP
  4. 4.Department of Hematology and Infectious Diseases, Karolinska Hospital, S-171 76 Stockholm, SwedenSE

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