Lung adenocarcinoma may be a more susceptive subtype to a dendritic cell-based cancer vaccine than other subtypes of non-small cell lung cancers: a multicenter retrospective analysis
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The J-SICT DC Vaccine Study Group provides dendritic cell (DC) vaccines for compassionate use under unified cell production and patient treatment regimens. We previously reported beneficial effects of DC vaccines on the overall survival of 62 patients with advanced non-small cell lung cancer (NSCLC) in a single-center analysis. Here, we extended analysis to 260 patients with NSCLC who were treated at six centers.
Of the 337 patients who met the inclusion criteria, we analyzed 260 patients who received ≥5 peptide-pulsed DC vaccinations once every 2 weeks.
The mean survival time (MST) from diagnosis was 33.0 months (95 % confidence interval [CI]: 27.9–39.2), and that from time of first vaccination was 13.8 months (95 % CI 11.4–16.8). An erythema reaction at the injection site that was ≥30 mm in diameter was correlated most strongly with overall survival from the first vaccine (≥30 vs. < 30 mm: MST 20.4 vs. 8.8 months, P < 0.001). We reported a similar finding in our previous analysis of patients with advanced pancreatic cancer. Interestingly, although such findings were common between patients with adenocarcinoma and those with other subtypes, the former group experienced significantly prolonged overall survival and a higher response rate for erythema (56.3 vs. 37.3 %, respectively, P = 0.014).
This is the first multicenter study that suggests a possible clinical benefit of DC vaccines for patients with advanced NSCLC, especially those with adenocarcinoma. These findings suggest a specific potential responder population for DC vaccines and warrant further investigation in well-controlled prospective randomized trials.
KeywordsNon-small cell lung cancers Adenocarcinoma Dendritic cell vaccine Erythema
Body mass index
Cell processing center
Common terminology criteria for adverse events
Disease control rate
Eastern Cooperative Oncology Group performance status
Institutional review board
The Japanese society of immunotherapy and cell therapy
Median survival time
Neutrophil to lymphocyte ratio
Non-small cell lung cancer
Peripheral blood mononuclear cell
Prognostic nutritional index
Squamous cell carcinoma
Standard operating procedure
Wilms’ tumor gene 1
This report is dedicated to the patients who participated in our studies and to their primary oncology doctors. We also thank the present and former staff of each participating institution.
Compliance with ethical standards
No funding supported this study.
Conflict of interest
Professor Y. Yonemitsu was a previous scientific advisor at tella, Inc., and Prof. M. Okamoto, who was excluded from data analyses, was a previous stockholder of tella, Inc. All remaining authors declare no conflicts of interest.
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