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Cancer Immunology, Immunotherapy

, Volume 65, Issue 8, pp 885–896 | Cite as

Pro- and anti-tumour effects of B cells and antibodies in cancer: a comparison of clinical studies and preclinical models

  • Thomas V. Guy
  • Alexandra M. Terry
  • Holly A. Bolton
  • David G. Hancock
  • Elena Shklovskaya
  • Barbara Fazekas de St Groth
Review

Abstract

The primary immune role of B cells is to produce antibodies, but they can also influence T cell function via antigen presentation and, in some contexts, immune regulation. Whether their roles in tumour immunity are similar to those in other chronic immune responses such as autoimmunity and chronic infection, where both pro- and anti-inflammatory roles have been described, remains controversial. Many studies have aimed to define the role of B cells in antitumor immune responses, but despite this considerable body of work, it is not yet possible to predict how they will affect immunity to any given tumour. In many human cancers, the presence of tumour-infiltrating B cells and tumour-reactive antibodies correlates with extended patient survival, and this clinical observation is supported by data from some animal models. On the other hand, T cell responses can be adversely affected by B cell production of immunoregulatory cytokines, a phenomenon that has been demonstrated in humans and in animal models. The isotype and concentration of tumour-reactive antibodies may also influence tumour progression. Recruitment of B cells into tumours may directly reflect the subtype and strength of the anti-tumour T cell response. As the response becomes chronic, B cells may attenuate T cell responses in an attempt to decrease host damage, similar to their described role in chronic infection and autoimmunity. Understanding how B cell responses in cancer are related to the effectiveness of the overall anti-tumour response is likely to aid in the development of new therapeutic interventions against cancer.

Keywords

B cells Antibodies Tumour models Clinical correlations 

Abbreviations

Breg

Regulatory B cell

CXCR3

CXC chemokine receptor 3

DMBA

7,12-Dimethylbenz[a]anthracene

FcR

Fc receptor

FcεRI

High affinity IgE receptor Fc epsilon RI

FcεRII

Low affinity IgE receptor Fc epsilon RII

Flt3L

FMS-like tyrosine kinase 3 ligand

GRP

Gastrin-releasing peptide

HSV1-TK

Herpes simplex virus 1 thymidine kinase

MCA

Methylcholanthrene

PSA

Prostate-specific antigen

SCC

Squamous cell carcinoma

SEREX

Serological identification of antigens by recombinant expression cloning

Th1

T helper type 1

TILs

Tumour-infiltrating lymphocytes

TPA

Tetradecanoyl phorbol acetate

VCAM-1

Vascular cell adhesion protein 1

Notes

Acknowledgments

This work was supported by National Health and Medical Research Council of Australia Grants 1012930 and 1051843 and Cancer Council New South Wales Grant RG13-13. Thomas Guy and David Hancock were recipients of Cancer Institute New South Wales Research Scholar awards, and Barbara Fazekas de St Groth was supported by a National Health and Medical Research Council of Australia Principal Research Fellowship.

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Thomas V. Guy
    • 1
    • 2
  • Alexandra M. Terry
    • 1
    • 2
  • Holly A. Bolton
    • 1
    • 2
  • David G. Hancock
    • 1
    • 2
  • Elena Shklovskaya
    • 1
    • 2
  • Barbara Fazekas de St Groth
    • 1
    • 2
  1. 1.T Cell Biology Research ProgramCentenary Institute of Cancer Medicine and Cell BiologyNewtownAustralia
  2. 2.Discipline of Dermatology, Sydney Medical SchoolThe University of SydneySydneyAustralia

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