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Cancer Immunology, Immunotherapy

, Volume 65, Issue 6, pp 765–767 | Cite as

A case report of insulin-dependent diabetes as immune-related toxicity of pembrolizumab: presentation, management and outcome

  • Elizabeth HansenEmail author
  • Deepak Sahasrabudhe
  • Lynn Sievert
Letter to the Editors

Dear Editors,

The article entitled “Anti-programmed cell death-1 therapy and insulin-dependent diabetes: a case report” provided an interesting perspective on the onset of insulin-dependent diabetes following anti-programmed cell death therapy [1]. While several recent reports cite the incidence of diabetes onset, little is mentioned on outcome or clinical course over time. Here we present a case of pembrolizumab-induced insulin-dependent diabetes, with insight on the clinical outcome following discontinuation of the offending agent.

Here we present a 58-year-old male, diagnosed with a 2.1-mm thick, Clark Level IV, non-ulcerated, cutaneous melanoma of the left upper arm in 2000. He underwent a wide excision and left axillary lymph node sampling, which revealed one of three lymph nodes to be involved. He was treated with interferon alpha 2B as adjuvant therapy for 1 year. In 2012, imaging revealed a right upper lobe lung nodule, left upper paramediastinal mass and lymphadenopathy in...

Keywords

Ipilimumab Vemurafenib Dabrafenib Axillary Lymph Node Sampling Harbor BRAF V600E 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Martin-Liberal J, Furness AJ, Joshi K, Peggs KS, Quezada SA, Larkin J (2015) Anti-programmed cell death-1 therapy and insulin-dependent diabetes: a case report. Cancer Immunol Immunother 64(6):765–767. doi: 10.1007/s00262-015-1689-1 CrossRefPubMedGoogle Scholar
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    Mekinist (trametinib) [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation (2015)   Google Scholar
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    Tafinlar (dabrafenib) [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation (2015)Google Scholar
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    Pembrolizumab (keytruda) [package insert]. Whitehouse Station, NJ: Merk & Co., Inc. (2015)Google Scholar
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    Keytruda (pembrolizumab) [package insert]. Merck & Co., Inc., Whitehouse Station, NJ (2014)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Elizabeth Hansen
    • 1
    Email author
  • Deepak Sahasrabudhe
    • 1
  • Lynn Sievert
    • 1
  1. 1.University of Rochester Medical CenterRochesterUSA

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