Cancer Immunology, Immunotherapy

, Volume 65, Issue 4, pp 453–463 | Cite as

Natural killer cell immunosenescence in acute myeloid leukaemia patients: new targets for immunotherapeutic strategies?

  • Beatriz Sanchez-Correa
  • Carmen Campos
  • Alejandra Pera
  • Juan M. Bergua
  • Maria Jose Arcos
  • Helena Bañas
  • Javier G. Casado
  • Sara Morgado
  • Esther Duran
  • Rafael Solana
  • Raquel Tarazona
Symposium-in-writing paper


Several age-associated changes in natural killer (NK) cell phenotype have been reported that contribute to the defective NK cell response observed in elderly patients. A remodelling of the NK cell compartment occurs in the elderly with a reduction in the output of immature CD56bright cells and an accumulation of highly differentiated CD56dim NK cells. Acute myeloid leukaemia (AML) is generally a disease of older adults. NK cells in AML patients show diminished expression of several activating receptors that contribute to impaired NK cell function and, in consequence, to AML blast escape from NK cell immunosurveillance. In AML patients, phenotypic changes in NK cells have been correlated with disease progression and survival. NK cell-based immunotherapy has emerged as a possibility for the treatment of AML patients. The understanding of age-associated alterations in NK cells is therefore necessary to define adequate therapeutic strategies in older AML patients.


AML Ageing DNAM-1 NK cells NKp46 NKp30 



Acute myeloid leukaemia


Acute myeloid leukaemia patient NK cells


Bispecific killer engagers


Chimeric antigen receptor




DNAX accessory molecule-1


Human leucocyte antigen




Innate lymphoid cells




Killer cell immunoglobulin-like receptors


Lymphokine-activated killer


Leucocyte immunoglobulin-like receptors


Major histocompatibility complex


MHC class I-related protein A


MHC class I-related protein B


Natural cytotoxicity receptors


Non-engrafting alloreactive cellular therapy


Natural killer


NK group 2, member D


Peripheral blood mononuclear cells


Tumour necrosis factor


Trispecific killer engagers


UL-16 binding protein


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Beatriz Sanchez-Correa
    • 1
  • Carmen Campos
    • 2
  • Alejandra Pera
    • 2
  • Juan M. Bergua
    • 3
  • Maria Jose Arcos
    • 3
  • Helena Bañas
    • 3
  • Javier G. Casado
    • 1
    • 4
  • Sara Morgado
    • 1
  • Esther Duran
    • 5
  • Rafael Solana
    • 2
  • Raquel Tarazona
    • 1
  1. 1.Immunology UnitUniversity of ExtremaduraCáceresSpain
  2. 2.Department of Immunology, IMIBICReina Sofia University Hospital, University of CordobaCórdobaSpain
  3. 3.Department of HematologyHospital San Pedro de AlcantaraCáceresSpain
  4. 4.Stem Cell Therapy UnitMinimally Invasive Surgery Centre Jesus UsonCáceresSpain
  5. 5.Histology and Pathology Unit, Faculty of VeterinaryUniversity of ExtremaduraCáceresSpain

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