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Cancer Immunology, Immunotherapy

, Volume 62, Issue 5, pp 919–929 | Cite as

Personalized peptide vaccination: a new approach for advanced cancer as therapeutic cancer vaccine

  • Masanori NoguchiEmail author
  • Tetsuro Sasada
  • Kyogo Itoh
Focussed Research Review

Abstract

Since both tumor cells and host immune cell repertoires are diverse and heterogeneous, immune responses against tumor-associated antigens should differ substantially among individual cancer patients. Selection of suitable peptide vaccines for individual patients based on the preexisting host immunity before vaccination could induce potent anti-tumor responses that provide clinical benefit to cancer patients. We have developed a novel immunotherapeutic approach of personalized peptide vaccination (PPV) in which a maximum of four human leukocyte antigen (HLA) class IA-matched peptides are selected for vaccination among pooled peptides on the basis of both HLA class IA type and the preexisting host immunity before vaccination. In this review, we discuss our recent results of preclinical and clinical studies of PPV for various types of advanced cancer.

Keywords

Immunotherapy Personalized peptide vaccine Cancer vaccine Advanced cancer 

Abbreviations

APC

Advanced pancreatic cancer

CR

Complete response

CRPC

Castration-resistant prostate cancer

CTL

Cytotoxic T lymphocytes

DBC

Docetaxel-based chemotherapy

EMP

Estramustine phosphate

GBM

Glioblastoma multiforme

GEM

Gemcitabine

HLA

Human leukocyte antigen

IgG

Immunoglobulin G

MHC

Major histocompatibility complex

MRP3

Multidrug resistance-associated protein 3

MST

Median survival time

NSLC

Non-small cell lung cancer

PBMC

Peripheral blood mononuclear cells

PAP

Prostatic acid phosphatase

PD

Progressive disease

PFS

Progression-free survival

PPV

Personalized peptide vaccine

PR

Partial response

PSA

Prostate-specific antigen

PSMA

Prostate-specific membrane antigen

SART

Squamous cell carcinoma antigen recognized by T cells

SCLC

Small cell lung cancer

TAA

Tumor-associated antigen

Notes

Conflict of interest

The authors indicated no potential conflict of interest except for Kyogo Itoh received a research grant from the Green Peptide Co., Ltd.; Kyogo Itoh own stock in the Green Peptide Co.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of UrologyKurume University School of MedicineKurumeJapan
  2. 2.Clinical Research Division of Research Center for Innovative Cancer TherapyKurume University School of MedicineKurumeJapan
  3. 3.Department of Immunology and ImmunotherapyKurume University School of MedicineKurumeJapan

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