Cancer Immunology, Immunotherapy

, Volume 62, Issue 5, pp 919–929 | Cite as

Personalized peptide vaccination: a new approach for advanced cancer as therapeutic cancer vaccine

  • Masanori NoguchiEmail author
  • Tetsuro Sasada
  • Kyogo Itoh
Focussed Research Review


Since both tumor cells and host immune cell repertoires are diverse and heterogeneous, immune responses against tumor-associated antigens should differ substantially among individual cancer patients. Selection of suitable peptide vaccines for individual patients based on the preexisting host immunity before vaccination could induce potent anti-tumor responses that provide clinical benefit to cancer patients. We have developed a novel immunotherapeutic approach of personalized peptide vaccination (PPV) in which a maximum of four human leukocyte antigen (HLA) class IA-matched peptides are selected for vaccination among pooled peptides on the basis of both HLA class IA type and the preexisting host immunity before vaccination. In this review, we discuss our recent results of preclinical and clinical studies of PPV for various types of advanced cancer.


Immunotherapy Personalized peptide vaccine Cancer vaccine Advanced cancer 



Advanced pancreatic cancer


Complete response


Castration-resistant prostate cancer


Cytotoxic T lymphocytes


Docetaxel-based chemotherapy


Estramustine phosphate


Glioblastoma multiforme




Human leukocyte antigen


Immunoglobulin G


Major histocompatibility complex


Multidrug resistance-associated protein 3


Median survival time


Non-small cell lung cancer


Peripheral blood mononuclear cells


Prostatic acid phosphatase


Progressive disease


Progression-free survival


Personalized peptide vaccine


Partial response


Prostate-specific antigen


Prostate-specific membrane antigen


Squamous cell carcinoma antigen recognized by T cells


Small cell lung cancer


Tumor-associated antigen


Conflict of interest

The authors indicated no potential conflict of interest except for Kyogo Itoh received a research grant from the Green Peptide Co., Ltd.; Kyogo Itoh own stock in the Green Peptide Co.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of UrologyKurume University School of MedicineKurumeJapan
  2. 2.Clinical Research Division of Research Center for Innovative Cancer TherapyKurume University School of MedicineKurumeJapan
  3. 3.Department of Immunology and ImmunotherapyKurume University School of MedicineKurumeJapan

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