Cancer Immunology, Immunotherapy

, Volume 61, Issue 1, pp 127–135 | Cite as

Muscle CARs and TcRs: turbo-charged technologies for the (T cell) masses

Focussed Research Review


A central role for T cells in the control of cancer has been supported by both animal models and clinical observations. Accordingly, the development of potent anti-tumor T cell immunity has been a long-standing objective of immunotherapy. Emerging data from clinical trials that test T cell immune-modulatory agents and genetically engineered and re-targeted T cells have begun to realize the profound potential of T cell immunotherapy to target cancer. This review will focus on a description of recent conceptual and technological advances for the genetic engineering of T cells to enhance anti-tumor T cell immunity through the introduction of tumor-specific receptors, both Chimeric Antigen Receptors (CAR) and T cell receptors (TcR), as well as an overview of emerging data from ongoing clinical trials that highlight the potential of these approaches to effect dramatic and potent anti-tumor immunity.


Chimeric antigen receptor T cell receptor Adoptive T cell transfer Immunotherapy Gene transfer CIMT 2011 



Effort for composing this manuscript was supported in part by funding from the University of Pennsylvania’s Institutional Clinical and Translational Science Award (CTSA), and by the Commonwealth of Pennsylvania/Pennsylvania Department of Health (grant# 4100051725).


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Abramson Family Cancer Research InstituteUniversity of PennsylvaniaPhiladelphiaUSA

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