Cancer Immunology, Immunotherapy

, Volume 59, Issue 4, pp 489–510

Regulation of immunity and oncogenesis by the IRF transcription factor family

  • David Savitsky
  • Tomohiko Tamura
  • Hideyuki Yanai
  • Tadatsugu Taniguchi
Review

DOI: 10.1007/s00262-009-0804-6

Cite this article as:
Savitsky, D., Tamura, T., Yanai, H. et al. Cancer Immunol Immunother (2010) 59: 489. doi:10.1007/s00262-009-0804-6

Abstract

Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis.

Keywords

Interferon regulatory factor Host defense Transcriptional regulation Immunity Oncogenesis 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • David Savitsky
    • 1
  • Tomohiko Tamura
    • 1
  • Hideyuki Yanai
    • 1
  • Tadatsugu Taniguchi
    • 1
  1. 1.Department of Immunology, Faculty of Medicine, Graduate School of MedicineThe University of TokyoTokyoJapan

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