Cancer Immunology, Immunotherapy

, Volume 57, Issue 10, pp 1541–1552 | Cite as

NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy

  • Karl-Johan Malmberg
  • Yenan T. Bryceson
  • Mattias Carlsten
  • Sandra Andersson
  • Andreas Björklund
  • Niklas K. Björkström
  • Bettina C. Baumann
  • Cyril Fauriat
  • Evren Alici
  • M. Sirac Dilber
  • Hans-Gustaf Ljunggren
Symposium Paper

Abstract

Insights into the molecular basis for natural killer (NK) cell recognition of human cancer have been obtained in recent years. Here, we review current knowledge on the molecular specificity and function of human NK cells. Evidence for NK cell targeting of human tumors is provided and new strategies for NK cell-based immunotherapy against human cancer are discussed. Based on current knowledge, we foresee a development where more cancers may be subject to treatment with drugs or other immunomodulatory agents affecting NK cells, either directly or indirectly. We also envisage a possibility that certain forms of cancers may be subject to treatment with adoptively transferred NK cells, either alone or in combination with other therapeutic interventions.

Keywords

NK cells Cancer Cytotoxicity Immunotherapy 

Abbreviations

AICD

Activation induced cell death

ADCC

Antibody mediated cellular cytotoxicity

AML

Acute myeloid leukemia

ATG

Anti-thymocyte globulin

ATM

Ataxia telangiectasia, mutated

ATR

ATM- and Rad3-related

CR

Complete remission

DC

Dendritic cell

DLI

Donor lymphocyte infusion

EBV

Epstein-Barr virus

Fas L

Fas ligand

Flt-3 L

Flt-3 ligand

GMP

Good manufacturing practice

GVH

Graft-versus-host

GVT

Graft-versus-tumor

GVHD

Graft-versus-host-disease

HLA

Human leukocyte antigen

IFN

Interferon

KIR

Killer-Ig-like receptors

LAK

Lymphokine activated killer

MHC

Major histocompatibility complex

NCR

Natural cytotoxicity receptor

NK

Natural killer

SCF

Stem cell factor

SCT

Stem cell transplantation

TNF

Tumor necrosis factor

Treg

Regulatory T

TRAIL

TNF-related apoptosis-inducing ligand

UL

Unique long

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Karl-Johan Malmberg
    • 1
  • Yenan T. Bryceson
    • 1
  • Mattias Carlsten
    • 1
  • Sandra Andersson
    • 1
  • Andreas Björklund
    • 1
  • Niklas K. Björkström
    • 1
  • Bettina C. Baumann
    • 1
  • Cyril Fauriat
    • 1
  • Evren Alici
    • 2
  • M. Sirac Dilber
    • 2
  • Hans-Gustaf Ljunggren
    • 1
  1. 1.Center for Infectious Medicine, Department of Medicine, Karolinska InstitutetKarolinska University Hospital HuddingeStockholmSweden
  2. 2.Division of Hematology, Department of Medicine Karolinska Institutet, Karolinska University Hospital HuddingeStockholmSweden

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