Cancer Immunology, Immunotherapy

, Volume 57, Issue 8, pp 1105–1114 | Cite as

Anti-angiogenic active immunotherapy: a new approach to cancer treatment

  • Jianping Pan
  • Pengfeng Jin
  • Jie Yan
  • Dieter Kabelitz


Tumor angiogenesis plays an important role in tumor growth, aggression and metastasis. Many molecules have been demonstrated as positive regulators of angiogenesis, including vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and others. In recent years, significant progress has been made in the research on anti-angiogenic strategies for tumor therapies. In this review, anti-angiogenic active immunotherapies for tumors based on vaccination with xenogeneic homologous molecules and non-xenogeneic homologous molecules are discussed.


Tumor Angiogenesis Active immunotherapy 



Vascular endothelial growth factor


Acidic fibroblast growth factor


Basic fibroblast growth factor


Epidermal growth factor (receptor)


Transforming growth factor-α/β


Placental growth factor


Endothelial cells


Early-outgrowth of endothelial progenitor cells


Recombinant eukaryotic expression plasmid harboring VEGF-encoding gene of mice


Recombinant eukaryotic expression plasmid harboring VEGF-encoding gene of Xenopus laevis


Fibroblast growth factor receptor-1




Soluble VEGFR-2 and IFN-γ fusion gene


Tumor associated macrophages



This work was supported by a grant from the Science and Technology Bureau of Zhejiang Province, P.R. China (No. 2005C23005).


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Jianping Pan
    • 1
  • Pengfeng Jin
    • 1
  • Jie Yan
    • 1
  • Dieter Kabelitz
    • 2
  1. 1.Department of Medical Microbiology and ParasitologyZhejiang University School of MedicineHangzhouPeople’s Republic of China
  2. 2.Institute of ImmunologyUniversitätsklinikum Schleswig-Holstein Campus KielKielGermany

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