Cancer Immunology, Immunotherapy

, Volume 56, Issue 2, pp 129–134 | Cite as

The strange case of TGN1412

  • L. Farzaneh
  • N. Kasahara
  • F. FarzanehEmail author

A current focus of cancer research is the development of immunostimulatory therapeutic antibodies, based on the notion that increasing the number or activity of cytotoxic T lymphocytes, and in particular those directed against tumour-associated antigens, may achieve effective immune mediated tumour rejection. Unlike other techniques, such as the use of antibodies specific to tumour cells themselves, this approach does not rely on antigen-specificity, and accordingly is subject to risks of autoimmunity as a consequence of non-specific activation of T cells [1].

The risks associated with such an approach have been placed firmly in the spotlight following the recent highly publicised suspension of Phase-I clinical testing of TGN1412 (see [2] for TGN1412 Investigator’s Brochure). This monoclonal antibody, one of a class of ‘superagonists’ for the immune co-stimulatory receptor CD28, was developed by TeGenero Immune Therapeutics (Würzburg, Germany) for the treatment of both autoimmune...


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.King’s College London, Department of Haematological and Molecular MedicineThe Rayne InstituteLondonUK
  2. 2.Department of Medicine, David Geffen School of MedicineUniversity of California Los AngelesLos AngelesUSA

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