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Cancer Immunology, Immunotherapy

, Volume 54, Issue 3, pp 187–207 | Cite as

A listing of human tumor antigens recognized by T cells: March 2004 update

  • Luisa Novellino
  • Chiara CastelliEmail author
  • Giorgio Parmiani
Review

Abstract

The technological advances occurred in the last few years have led to a great increase in the number of tumor associated antigens (TAA) that are currently available for clinical applications. In this review we provide a comprehensive list of human tumor antigens as reported in the literature updated at Feburary 2004. The list includes all T cell-defined epitopes, while excluding analogs or artificially modified epitopes, as well as virus-encoded and antibodies-recognized antigens. TAAs are listed in alphabetical order along with the epitope sequence and the HLA allele which restricts recognition by T cells. Data on the tissue distribution of each antigen are also provided together with an extensive bibliography that allows a rapid search for any additional information may be needed on each single antigen or epitope. Overall, the updated list is a database tool for clinicians, scientists and students who have an interest in the field of tumor immunology and immunotherapy.

Keywords

Antigens Epitopes T cells Tumor 

Abbreviations

AFP

Alpha (α)-fetoprotein

AIM-2

Interferon-inducible protein absent in melanoma 2

ALL

Acute lymphoblastic leukemia

AML

Acute myeloid leukemia

707-AP

707 alanine proline

APL

Acute promyelocytic leukemia

ART-4

Adenocarcinoma antigen recognized by T cells 4

BAGE

B antigen

bcr-abl

Breakpoint cluster region-Abelson

CAMEL

CTL-recognized antigen on melanoma

CAP-1

Carcinoembryonic antigen peptide-1

CASP-8

Caspase 8

CDC27

Cell division cycle 27

CDK4

Cyclin-dependent kinase 4

CEA

Carcinoembryonic antigen

CLCA2

Calcium-activated chloride channel 2

CML

Chronic myelogenous leukemia

CT

Cancer-testis (antigen)

CTL

Cytotoxic T lymphocytes

Cyp-B

Cyclophilin B

DAM

Differentiation antigen melanoma (the epitopes of DAM-6 and DAM-10 are equivalent, but the gene sequences are different. DAM-6 is also called MAGE-B2 and DAM-10 is also called MAGE-B1)

ELF2

Elongation factor 2

Ep-CAM

Epithelial cell adhesion molecule

EphA2, 3

Ephrin type-A receptor 2, 3

Ets

E-26 transforming specific (family of transcription factors)

ETV6-AML1

Ets variant gene 6 / acute myeloid leukemia 1 gene ETS

FGF-5

Fibroblast growth factor 5

FN

Fibronectin

G250

Glycoprotein 250

GAGE

G antigen

GnT-V

N-Acetylglucosaminyltransferase V

Gp100

Glycoprotein 100 kDa

HAGE

Helicase antigen

HER-2/neu

Human epidermal receptor 2/neurological

HLA-A*0201-R170I

Arginine (R) to isoleucine (I) exchange at residue 170 of the α-helix of the α2-domain in the HLA-A2 gene

H/N

Head and neck

HSP70-2 M

Heat shock protein 70-2 mutated

HST-2

Human signet-ring tumor 2

hTERT

Human telomerase reverse transcriptase

iCE

Intestinal carboxyl esterase

IL-13Rα2

Interleukin 13 receptor α2 chain

KIAA0205

Name of the gene as it appears in databases

LAGE

L antigen

LDLR/FUT

Low density lipid receptor / GDP-L-fucose:β-D-galactosidase 2-α-L-fucosyltransferase

MAGE

Melanoma antigen

MART-1/Melan-A

Melanoma antigen recognized by T cells-1 / melanoma antigen A

MART-2

Melanoma Ag recognized by T cells-2

MC1R

Melanocortin 1 receptor

M-CSF

Macrophage colony-stimulating factor gene

MHC

Major histocompatibility complex

MSI

Microsatellite instability

MUC1, 2

Mucin 1, 2

MUM-1, -2, -3

Melanoma ubiquitous mutated 1, 2, 3

NA88-A

NA cDNA clone of patient M88

Neo-PAP

Neo-poly(A) polymerase

NPM/ALK

Nucleophosmin/anaplastic lymphoma kinase fusion protein

NSCLC

Non–small cell lung carcinoma

NY-ESO-1

New York esophageous 1

OA1

Ocular albinism type 1 protein

OGT

O-Linked N-acetylglucosamine transferase gene

ORF

Open reading frame

OS-9

Name of the gene as it appears in databases

P15

Protein 15

p190 minor bcr-abl

Protein of 190-kDa bcr-abl

Pml/RARα

Promyelocytic leukemia / retinoic acid receptor α

PRAME

Preferentially expressed antigen of melanoma

PSA

Prostate-specific antigen

PSMA

Prostate-specific membrane antigen

PTPRK

Receptor-type protein-tyrosine phosphatase kappa

RAGE

Renal antigen

RCC

Renal cell carcinoma

RU1, 2

Renal ubiquitous 1, 2

SAGE

Sarcoma antigen

SART-1, -2, -3

Squamous antigen rejecting tumor 1, 2, 3

SCC

Squamous cell carcinoma

SSX-2

Synovial sarcoma, X breakpoint 2

Survivin-2B

Intron 2-retaining survivin

SYT/SSX

Synaptotagmin I / synovial sarcoma, X fusion protein

TAA

Tumor-associated antigen

TEL/AML1

Translocation Ets-family leukemia/acute myeloid leukemia 1

TGFβRII

Transforming growth factor β receptor 2

TPI

Triosephosphate isomerase

TRAG-3

Taxol resistant associated protein 3

TRG

Testin-related gene

TRP-1

Tyrosinase-related protein 1, or gp75

TRP-2

Tyrosinase-related protein 2

TRP-2/INT2

TRP-2/intron 2

TRP-2/6b

TRP-2/novel exon 6b

TSTA

Tumor-specific transplantation antigens

WT1

Wilms’ tumor gene

Notes

Acknowledgements

The authors would like to thank Ms Grazia Barp for editorial assistance. This work was supported in part by a grant of the European Community (QLK3-1999-00064) and the Italian Ministry of Education, University and Research (Rome, FIRB RBNE017B4C).

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Luisa Novellino
    • 1
  • Chiara Castelli
    • 1
    Email author
  • Giorgio Parmiani
    • 1
  1. 1.Unit of Immunotherapy of Human TumorsIstituto Nazionale TumoriMilanItaly

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