Cancer Immunology, Immunotherapy

, Volume 53, Issue 3, pp 249–255 | Cite as

Monitoring tumor antigen specific T-cell responses in cancer patients and phase I clinical trials of peptide-based vaccination

  • Pedro Romero
  • Jean-Charles Cerottini
  • Daniel E. Speiser
Review

Abstract

Numerous phase I and II clinical trials testing the safety and immunogenicity of various peptide vaccine formulations based on CTL-defined tumor antigens in cancer patients have been reported during the last 7 years. While specific T-cell responses can be detected in a variable fraction of immunized patients, an even smaller but significant fraction of these patients have objective tumor responses. Efficient therapeutic vaccination should aim at boosting naturally occurring antitumor T- and B-cell responses and at sustaining a large number of tumor antigen specific and fully functional effector T cells at tumor sites. Recent progress in our ability to quantitatively and qualitatively monitor tumor antigen specific CD8 T-cell responses will greatly help in making rapid progress in this field.

Keywords

Cancer vaccines Tumor immunology Immune monitoring Tetramers 

Notes

Acknowledgements

This work was supported in part by funds from the NCCR Molecular Oncology.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Pedro Romero
    • 1
  • Jean-Charles Cerottini
    • 2
  • Daniel E. Speiser
    • 1
  1. 1.Divison of Clinical Onco-Immunology, Lausanne branch, University Hospital (CHUV)Ludwig Institute for Cancer ResearchLausanneSwitzerland
  2. 2.Lausanne BranchLudwig Institute for Cancer ResearchEpalingesSwitzerland

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