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Cancer Immunology, Immunotherapy

, Volume 51, Issue 6, pp 293–298 | Cite as

Immature myeloid cells and cancer-associated immune suppression

  • Sergei Kusmartsev
  • Dmitry I. Gabrilovich
Review

Abstract.

Impaired balance between mature and immature myeloid cells is one of the hallmarks of cancer. In cancer patients as well as in mouse models there is increasing evidence that progressive tumor growth is associated with an accumulation of immature myeloid cells, monocytes/macrophages, and with a decreased number and function of dendritic cells (DC). This review examines recent findings on the contribution of immature myeloid cells (ImC) to cancer-induced immune suppression.

Cancer Immature myeloid cell Immune suppression Immune tolerance T-cell response 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Sergei Kusmartsev
    • 1
  • Dmitry I. Gabrilovich
    • 1
  1. 1.H. Lee Moffitt Cancer Center, University of South Florida, MRC-2, Room 2067, 12902 Magnolia Drive, Tampa, FL 33612, USA

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