Cancer Immunology, Immunotherapy

, Volume 51, Issue 5, pp 235–247

The role of CD8+ T cells in immune responses to colorectal cancer

  • Liviu V. Titu
  • John R. Monson
  • John Greenman
Review

Abstract

Cytotoxic T lymphocytes (CTL) are essential effectors of the cell-mediated immune response. The ability of CTL to specifically recognise and lyse malignant cells expressing the relevant surface antigens under optimal in vitro conditions justifies attempts to boost their number and activity through various forms of immunotherapy. Considering the high prevalence of colorectal cancer and poor survival rates for patients with advanced-stage disease, the development of new protocols based on CTL stimulation represents a genuine and promising treatment option. Significant advances in recombinant DNA technology and molecular biology have led to the identification of a number of tumour-associated antigens (TAA). These have served as vaccine constituents and/or stimuli for obtaining CTL used for adoptive immunotherapy after in vitro stimulation and expansion. The present review describes the properties and functions of CTL as effectors of the immune response against tumours, and summarises the known TAA recognised by CTL and the current status of CTL-related immunotherapeutic interventions in colorectal cancer patients.

Colorectal cancer Cytotoxic T lymphocyte Immunity 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Liviu V. Titu
    • 1
  • John R. Monson
    • 1
  • John Greenman
    • 1
  1. 1.Academic Surgical Unit, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Hull, HU16 5JQ, United KingdomUK
  2. 2.Medical Research Laboratory, Wolfson Building, University of Hull, Cottingham Road, Hull, HU6 7RX, United KingdomUK

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