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Malignant peritoneal mesothelioma: correlation between CT imaging features and histologic subtypes

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Abstract

Purpose

To identify correlation between CT imaging features and histologic subtypes of Malignant Peritoneal Mesothelioma (MPM).

Methods

This was a retrospective single-center study of 51 consecutive patients with the diagnosis of Malignant Peritoneal Mesothelioma (MPM). The tumors were classified into pure epithelioid type and those with sarcomatoid component (pure sarcomatoid and biphasic type). Imaging features of these subtypes were compared for extent and type of peritoneal thickening, omental thickening, abdominal visceral infiltration, abdominal wall infiltration, and loco-regional and distant metastases. Fisher’s Exact test was used to correlate the association of imaging features with histology types followed by multivariate analysis using logistic regression test.

Results

32 males and 19 females with a median age of 63 years (range 35–86 years) were included in the study. 41/51 (80%) were epithelioid histology type and 10/51 (20%) had sarcomatoid component (3 pure sarcomatoid type, 7 biphasic type). Abdominal visceral infiltration was seen more commonly in cases of MPM with sarcomatoid component (p = 0.001). Sarcomatoid type also had a frequent association with metastases (p = 0.001) and discrete masses (p = 0.01). Epithelioid type was commonly associated with ascites (p = 0.04). On multivariate analysis, most significant correlation was identified between the sarcomatoid type and imaging features of metastases (p = 0.001) and visceral infiltration (p = 0.019).

Conclusion

Sarcomatoid type of MPM showed significant correlation with more aggressive imaging features of metastases and visceral infiltration as compared to epithelioid type.

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Abbreviations

MPM:

Malignant Peritoneal Mesothelioma

CT:

Computed Tomography

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No funding was received for this research study.

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Authors and Affiliations

  1. Division of Abdominal Imaging, Department of Radiology, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA

    Isha D. Atre & Mukesh G. Harisinghani

  2. Department of Radiology, Allegheny General Hospital, 320 E North Avenue, PA, Pittsburgh, 15212, USA

    Gaurav V. Watane

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  1. Isha D. Atre
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Correspondence to Isha D. Atre.

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Atre, I.D., Watane, G.V. & Harisinghani, M.G. Malignant peritoneal mesothelioma: correlation between CT imaging features and histologic subtypes. Abdom Radiol 46, 5105–5113 (2021). https://doi.org/10.1007/s00261-021-03231-4

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