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Association between chronic asymptomatic pancreatic hyperenzymemia and pancreatic ductal anomalies: a magnetic resonance cholangiopancreatography study

  • Wataru GonoiEmail author
  • Takana Yamakawa Hayashi
  • Naoto Hayashi
  • Osamu Abe
Pancreas
  • 51 Downloads

Abstract

Purpose

Elucidating the association between pancreatic ductal anomalies and chronic asymptomatic pancreatic hyperenzymemia using magnetic resonance cholangiopancreatography.

Methods

We conducted a single-center, retrospective, case–control study. The healthy community group comprised 554 subjects who participated in a paid, whole-body health checkup program. The patient group comprised 14 subjects with idiopathic pancreatic hyperamylasemia or hyperlipasemia. All subjects underwent magnetic resonance cholangiopancreatography. The clinical features and incidence rates of pancreatic ductal anomalies were then compared between the groups.

Results

Compared to the healthy community group, the patient group was significantly more likely to be ≥ age 65 (71.4% of patient group vs. 22.1% of healthy community group), have a history of diabetes mellitus (21.4% vs. 5.4%) or hypertension (35.7% vs. 11.4%), and to have pancreas divisum (21.4% vs. 2.7%), meandering main pancreatic duct (21.4% vs. 4.1%), Wirsungocele (14.3% vs. 1.1%), or dilated main pancreatic duct (14.3% vs. 2.3%). Multivariate analysis found that age ≥ 65 (odds ratio 8.76), presence of pancreas divisum (odds ratio 13.2), meandering main pancreatic duct (odds ratio 8.95), and Wirsungocele (odds ratio 17.6) were independent factors significantly associated with chronic asymptomatic pancreatic hyperenzymemia.

Conclusions

Pancreas divisum, meandering main pancreatic duct, and Wirsungocele were independently associated with chronic asymptomatic pancreatic hyperenzymemia.

Keywords

Amylase Lipase Magnetic resonance imaging Pancreatitis 

Notes

Funding

This work was supported by JSPS KAKENHI Grant Number JP25870148.

Compliance with ethical standards

Conflict of interest

All authors have no conflict of interest to declare.

Ethical approval

Our Institutional Review Board approved this STROBE-compliant single-center retrospective case–control study.

Informed consent

Our Institutional Review Board waived informed consent for this STROBE-compliant single-center retrospective case–control study.

STROBE statement

We confirm that this study is STROBE-compliant.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Radiology, Graduate School of MedicineThe University of TokyoTokyoJapan
  2. 2.Computational Diagnostic Radiology and Preventive MedicineThe University of TokyoTokyoJapan

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