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A comparative study of MR extracellular volume fraction measurement and two-dimensional shear-wave elastography in assessment of liver fibrosis with chronic hepatitis B

  • Kaipu Jin
  • Heqing Wang
  • Mengsu Zeng
  • Shengxiang Rao
  • Lixia Yan
  • Yuan Ji
  • Caixia Fu
  • Ruofan Sheng
Hepatobiliary
  • 1 Downloads

Abstract

Objective

To evaluate the value of MR liver extracellular volume (ECVliver) in assessment of liver fibrosis with chronic hepatitis B (CHB), and to compare its performance with two-dimensional (2D) shear-wave elastography (SWE).

Materials and methods

A total of 68 CHB patients who were histologically diagnosed as fibrosis stages F0 to F4 were retrospectively analyzed. All patients underwent gadopentetate dimeglumine-enhanced T1-mapping and 2D SWE. ECVliver and liver stiffness were measured and compared between fibrosis subgroups; their correlations with histologic findings were evaluated using Spearman correlation test and multiple regression analysis. Diagnostic performance in evaluating liver fibrosis stages was assessed and compared using receiver-operating characteristic analysis.

Results

Both ECVliver and liver stiffness increased as the fibrosis score increased (F = 17.08 to 10.99, P < 0.001). ECVliver displayed a strong correlation with fibrosis stage (r = 0.740, P < 0.001), and liver stiffness displayed a moderate correlation (r = 0.651, P < 0.001); multivariate analysis revealed that only ECVliver was independently correlated with fibrosis stage (P < 0.001). Univariate analyses showed significant correlations of ECVliver with fibrosis stage, inflammatory activity, and platelet count; among all, the fibrosis stage had the highest correlation coefficient and was the only independent factor (P < 0.001). Overall, ECVliver had no significant different performance compared with 2D SWE for the identification of both fibrosis stage s ≥ F2 and F4 (P = 0.868 and 0.171).

Conclusion

MR ECVliver plays a promising role in the prediction of liver fibrosis for patients with CHB, comparable to 2D SWE.

Keywords

Liver fibrosis Extracellular space Magnetic resonance imaging Sonoelastography Chronic hepatitis B Cirrhosis 

Notes

Funding

This work was supported by the National Natural Science Foundation for Young Scientists of China [grant number 81601488]; the Shanghai Sailing Program [grant number 16YF1410600]; and the National Natural Science Foundation of China [grant number 81571661].

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of RadiologyZhongshan Hospital, Fudan University, Shanghai Institute of Medical ImagingShanghaiPeople’s Republic of China
  2. 2.Department of UltrasoundZhongshan Hospital, Fudan UniversityShanghaiPeople’s Republic of China
  3. 3.Department of PathologyZhongshan Hospital, Fudan UniversityShanghaiPeople’s Republic of China
  4. 4.Siemens HealthcareShanghaiPeople’s Republic of China

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