PET/CT in brachytherapy early response evaluation of pancreatic ductal adenocarcinoma xenografts: comparison with apparent diffusion coefficient from diffusion-weighted MR imaging
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To evaluate the feasibility of using PET/CT and diffusion-weighted magnetic resonance imaging (DW-MRI) to monitor the early response of pancreatic ductal adenocarcinoma (PDAC) xenografts to brachytherapy, and to determine whether maximum standardized uptake value (SUVmax) correlate with apparent diffusion coefficient (ADC).
Materials and Methods
SW1990 human PDAC were subcutaneously implanted in 20 nude mice. They were randomly divided into 125-Iodine (125I) seeds and blank seeds group. PET/CT and DW-MRI were performed at pretreatment and 5 days after therapy. SUVmax and ADC values were calculated, respectively. The correlation between SUVmax and ADC values was analyzed by the Pearson correlation test.
The SUVmax were significantly decreased between pretreatment and 5 days after 125I seeds treatment (p < 0.001) and between two groups (p < 0.001). And the ADC values were significantly increased between pretreatment and 5 days after 125I seeds treatment (p < 0.001) and between two groups (p < 0.001). While in the bank seeds group, there were no significantly difference between pretreatment and after treatment in SUVmax and ADC values (p = 0.057; p = 0.397). SUVmax and ADC correlated significantly and negatively before treatment in both groups (r = − 0.964, R2 = 0.929, p < 0.001; r = − 0.917, R2 = 0.841, p < 0.001) and after treatment in the blank seeds group (r = − 0.944, R2 = 0.891, p < 0.001). But after 125I seeds treatment there was no significant correlation between SUVmax and ADC (r = − 0.388, R2 = 0.151, p = 0.268).
The PET/CT and DW-MRI are capable of monitoring the early response of PDAC xenografts to brachytherapy. The significantly inverse correlation between pretreatment SUVmax and ADC suggests that PET/CT and DW-MRI might play complementary roles for therapy assessment.
KeywordsIodine-125 seeds Brachytherapy Pancreatic ductal adenocarcinoma Xenografts 18F-FDG PET/CT Diffusion-weighted MRI
This work was supported by Grants from the National Natural Science Foundation of China (81401455).
Compliance with ethical standards
Yu Liu has received Grants from National Natural Science Foundation of China (81401455). For the remaining authors none were declared.
Conflict of interest
All authors have no any financial and personal relationships with other people or organisations that could inappropriately influence (bias) their work.
- 1.Niu H, Zhang X, Wang B, et al. (1058) The clinical utility of image-guided iodine-125 seed in patients with unresectable pancreatic cancer. Br J Radiol 2016(89):20150573Google Scholar
- 2.Ergul N, Gundogan C, Tozlu M, et al. (2014) Role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography in diagnosis and management of pancreatic cancer; comparison with multidetector row computed tomography, magnetic resonance imaging and endoscopic ultrasonography. Rev Esp Med Nucl Imagen Mol 33(3):159–164PubMedGoogle Scholar
- 3.Min M, Lee MT, Lin P, et al. (1058) Assessment of serial multi-parametric functional MRI (diffusion-weighted imaging and R2*) with (18)F-FDG-PET in patients with head and neck cancer treated with radiation therapy. Br J Radiol 2016(89):20150530Google Scholar
- 7.Tsuchida T, Morikawa M, Demura Y, et al. (2013) Imaging the early response to chemotherapy in advanced lung cancer with diffusion-weighted magnetic resonance imaging compared to fluorine-18 fluorodeoxyglucose positron emission tomography and computed tomography. J Magn Reson Imaging 38(1):80–88CrossRefGoogle Scholar
- 8.Liu Y, Liu X, Gao W, et al. (2017) Combining DCE-MRI and 18F-FDG PET/CT for monitoring the efficacy of 125I seed brachytherapy in nude mice bearing pancreatic cancer xenografts. Chin J Med Phys 34(01):1–6 (Chinese)Google Scholar
- 12.Hu S, Shi X, Chen Y, et al. (1058) Functional imaging of interstitial brachytherapy in pancreatic carcinoma xenografts using spectral CT: how does iodine concentration correlate with standardized uptake value of (18)FDG-PET-CT? Br J Radiol 2016(89):20150573Google Scholar