Abdominal Radiology

, Volume 44, Issue 1, pp 209–217 | Cite as

Magnetic resonance imaging findings of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in adults: a pilot study

  • Chenchen Dai
  • Ruofan Sheng
  • Yuqin Ding
  • Minglei Yang
  • Jun Hou
  • Jianjun ZhouEmail author



The purpose of the study was to retrospectively analyze MRI findings of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2/TFE RCC) in adults.


Sixteen patients with Xp11.2/TFE RCC were reviewed retrospectively. The clinical characteristics and imaging features were assessed and then compared between metastatic and non-metastatic subgroups.


The mean age at diagnosis was 47.4 (20–76) years. Seven (44 %) patients were men, and nine (56 %) patients were women. The lesions predominantly exhibited an endophytic distribution (n = 14, 88 %) with a capsule (n = 16, 100 %), accompanied by solid and cystic patterns (n = 12, 75%) and hemorrhage (n = 11, 69 %). The tumors prevalently appeared hyper- to isointense on T1WI (n = 14, 88 %), hypointense on T2WI (n = 13, 81 %), and hyperintense on DWI (n = 16, 100 %) with a lower ADC (P < 0.001) than that of the surrounding tissue. The tumors were less enhanced than the normal renal cortex in all phases with a prolonged enhancement pattern (P ≤ 0.001). In addition, six patients (38 %) developed recurrence or metastases. The RCCs with metastases showed an irregular shape (P = 0.013), an incomplete capsule (P = 0.018), heterogeneous solid-cystic patterns (P = 0.034), and hemorrhage (P = 0.037) than non-metastatic subgroups.


MRI provides valuable information for the diagnosis of adult Xp11.2/TFE RCCs. Features including irregular shape, incomplete capsule, mixed solid-cystic pattern, and hemorrhage may indicate the occurrence of recurrence or metastases.


Renal cell carcinoma Adult Magnetic resonance imaging Diagnosis Prognosis 



World Health Organization


Renal cell carcinoma

Xp11.2/TFE RCC

Xp11.2 Translocation/TFE3 gene fusion renal cell carcinoma


Computed tomography


Positron emission tomography-computed tomography


Diffusion-weighted imaging


Apparent diffusion coefficient




Fluorescence in situ hybridization


Region of interest



The authors state that this work has not received any funding.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Chenchen Dai
    • 1
    • 2
    • 3
  • Ruofan Sheng
    • 1
    • 2
    • 3
  • Yuqin Ding
    • 1
    • 2
    • 3
  • Minglei Yang
    • 4
  • Jun Hou
    • 5
  • Jianjun Zhou
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Radiology, Zhongshan HospitalFudan UniversityShanghaiChina
  2. 2.Shanghai Institute of Medical ImagingShanghaiChina
  3. 3.Department of Medical Imaging, Shanghai Medical CollegeFudan UniversityShanghaiChina
  4. 4.Siemems HealthineersShanghaiChina
  5. 5.Department of Pathology, Zhongshan HospitalFudan UniversityShanghaiChina

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