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Hemobilia after CT-guided radiofrequency ablation of liver tumors: frequency, risk factors, and clinical significance

  • Mei-Fang Hsieh
  • Chia-Bang Chen
  • Yao-Li Chen
  • Chen-Te Chou
Article
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Abstract

Purpose

The purpose of the study is to evaluate the frequency, risk factors, and clinical significance of hemobilia after percutaneous computed tomography (CT)-guided radiofrequency ablation (RFA) of liver tumors.

Materials and methods

From January 2013 to September 2016, 195 patients received 267 sessions of CT-guided RFA for liver tumors at our institution. The CT images during and immediately after the RFA were retrospectively reviewed. The frequency of hemobilia development and clinical outcome of patients with hemobilia were studied. Risk factors were identified by comparison between the hemobilia and non-hemobilia groups using univariate and multivariate analysis. The clinical courses of patients with hemobilia were also reviewed.

Results

The frequency of CT detected hemobilia after RFA was 8.2% (22/267). The majority of the clinical courses were self-limited. Univariate analysis showed that the tumor numbers (p = 0.015), the central type puncture track (p < 0.001), the length of the puncture track (p = 0.033), and the platelet count (p = 0.026) were significantly associated with the development of hemobilia. Multivariate analysis demonstrated that the central type puncture track (p < 0.024) and the platelet count (p = 0.023) were significant independent risk factors.

Conclusion

Detection of hemobilia on CT images immediately after percutaneous RFA for liver tumors was not rare. Low platelet count and central type puncture track are independent risk factors. In most cases, hemobilia presented as a minor complication with favorable prognosis.

Keywords

Hemobilia CT-guided radiofrequency ablation Hepatocellular carcinoma Liver tumors Complication 
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Notes

Compliance with ethical standards

Conflict of interest

All author have no conflict of interest.

Ethical approval

The study was approved by the IRB board of Changhua Christian Hospital.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Mei-Fang Hsieh
    • 1
  • Chia-Bang Chen
    • 1
  • Yao-Li Chen
    • 2
    • 3
  • Chen-Te Chou
    • 1
    • 3
    • 4
    • 5
  1. 1.Department of RadiologyChanghua Christian HospitalChanghua CityTaiwan
  2. 2.Transplant Medicine and Surgery Research CentreChanghua Christian HospitalChanghua CityTaiwan
  3. 3.School of MedicineKaohsiung Medical UniversityKaohsiung CityTaiwan
  4. 4.Department of Biomedical Imaging and Radiological SciencesNational Yang-Ming Medical UniversityTaipei CityTaiwan
  5. 5.Department of Molecular Biotechnology, College of Biotechnology and BioresourcesDayeh UniversityChanghua CityTaiwan

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