Tubulocystic renal cell carcinoma: a review of literature focused on radiological findings for differential diagnosis
- 260 Downloads
Tubulocystic renal cell carcinoma (TC-RCC) has been classified as an independent subtype according to the 2016 World Health Organization (WHO) classification. It is a rare subtype that predominantly affects men. Although few in number, radiological imaging reports have suggested that TC-RCC is characterized by multilocular cystic lesions, which are categorized as the Bosniak classification II–IV, with signature pathological characteristics comprising numerous small cysts or a tubular structure. The Bosniak classification system facilitates patient management; however, the differentiation of cystic tumors exhibiting similar imaging findings remains impossible; in fact, the differentiation of multilocular cystic RCC, adult cystic nephroma, and mixed epithelial and stromal tumor remains challenging. This review aims to discuss TC-RCC with a focus on implications of radiological findings in the differential diagnosis of TC-RCC.
KeywordsTubulocystic renal cell carcinoma Multilocular cystic renal cell carcinoma Mixed epithelial and stromal tumor MRI CT US
Tubulocystic renal cell carcinoma
Renal cell carcinoma
World Health Organization
Papillary renal cell carcinoma
Mixed epithelial and stromal tumor
Magnetic resonance imaging
Compliance with ethical standards
This study has received a research grant from Bayer Pharm, Osaka, Japan.
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
The current retrospective study was approved by the institutional review board of our institution and informed consent from patients was waived.
- 12.Lawrie CH, Armesto M, Fernandez-Mercado M, et al. (2018) Noncoding RNA expression and targeted next-generation sequencing distinguish tubulocystic renal cell carcinoma (TC-RCC) from other renal neoplasms. J Mol Diagn 20(1):34–45. https://doi.org/10.1016/j.jmoldx.2017.09.002 CrossRefPubMedGoogle Scholar