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Abdominal Radiology

, Volume 43, Issue 7, pp 1540–1545 | Cite as

Tubulocystic renal cell carcinoma: a review of literature focused on radiological findings for differential diagnosis

  • Yukiko HondaEmail author
  • Yuko Nakamura
  • Keisuke Goto
  • Hiroaki Terada
  • Kazuhiro Sentani
  • Wataru Yasui
  • Yohei Sekino
  • Tetsutaro Hayashi
  • Jun Teishima
  • Akio Matsubara
  • Motonori Akagi
  • Tomoyo Fuji
  • Yasutaka Baba
  • Makoto Iida
  • Kazuo Awai
Pictorial essay
  • 260 Downloads

Abstract

Tubulocystic renal cell carcinoma (TC-RCC) has been classified as an independent subtype according to the 2016 World Health Organization (WHO) classification. It is a rare subtype that predominantly affects men. Although few in number, radiological imaging reports have suggested that TC-RCC is characterized by multilocular cystic lesions, which are categorized as the Bosniak classification II–IV, with signature pathological characteristics comprising numerous small cysts or a tubular structure. The Bosniak classification system facilitates patient management; however, the differentiation of cystic tumors exhibiting similar imaging findings remains impossible; in fact, the differentiation of multilocular cystic RCC, adult cystic nephroma, and mixed epithelial and stromal tumor remains challenging. This review aims to discuss TC-RCC with a focus on implications of radiological findings in the differential diagnosis of TC-RCC.

Keywords

Tubulocystic renal cell carcinoma Multilocular cystic renal cell carcinoma Mixed epithelial and stromal tumor MRI CT US 

Abbreviations

TC-RCC

Tubulocystic renal cell carcinoma

RCC

Renal cell carcinoma

WHO

World Health Organization

P-RCC

Papillary renal cell carcinoma

MEST

Mixed epithelial and stromal tumor

MRI

Magnetic resonance imaging

CT

Computed tomography

US

Ultrasonography

Notes

Compliance with ethical standards

Funding

This study has received a research grant from Bayer Pharm, Osaka, Japan.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

The current retrospective study was approved by the institutional review board of our institution and informed consent from patients was waived.

References

  1. 1.
    Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (2016) The 2016 WHO classification of tumours of the urinary system and male genital organs-part a: renal, penile, and testicular tumours. Eur Urol 70(1):93–105.  https://doi.org/10.1016/j.eururo.2016.02.029 CrossRefPubMedGoogle Scholar
  2. 2.
    MacLennan GT, Farrow GM, Bostwick DG (1997) Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. Urology 50(5):679–684.  https://doi.org/10.1016/s0090-4295(97)00335-x CrossRefPubMedGoogle Scholar
  3. 3.
    MacLennan GT, Bostwick DG (2005) Tubulocystic carcinoma, mucinous tubular and spindle cell carcinoma, and other recently described rare renal tumors. Clin Lab Med 25(2):393–416.  https://doi.org/10.1016/j.cll.2005.01.005 CrossRefPubMedGoogle Scholar
  4. 4.
    Osunkoya AO, Young AN, Wang W, Netto GJ, Epstein JI (2009) Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidney. Am J Surg Pathol 33(7):1103–1106.  https://doi.org/10.1097/PAS.0b013e3181a13e7b CrossRefPubMedGoogle Scholar
  5. 5.
    Zhou M, Yang XJ, Lopez JI, et al. (2009) Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification. Am J Surg Pathol 33(12):1840–1849.  https://doi.org/10.1097/PAS.0b013e3181be22d1 CrossRefPubMedGoogle Scholar
  6. 6.
    Yang XJ, Zhou M, Hes O, et al. (2008) Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization. Am J Surg Pathol 32(2):177–187.  https://doi.org/10.1097/PAS.0b013e318150df1d CrossRefPubMedGoogle Scholar
  7. 7.
    Nagashima Y, Kuroda N, Yao M (2013) Transition of organizational category on renal cancer. Jpn J Clin Oncol 43(3):233–242.  https://doi.org/10.1093/jjco/hyt006 CrossRefPubMedGoogle Scholar
  8. 8.
    Kuroda N, Matsumoto H, Ohe C, et al. (2013) Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects. Pol J Pathol 64(4):233–237CrossRefPubMedGoogle Scholar
  9. 9.
    Ishibashi Y, Koie T, Fujita N, et al. (2014) Tubulocystic renal cell carcinoma in the left kidney: a case report. J Med Case Rep 8:265.  https://doi.org/10.1186/1752-1947-8-265 CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Amin MB, MacLennan GT, Gupta R, et al. (2009) Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. Am J Surg Pathol 33(3):384–392.  https://doi.org/10.1097/PAS.0b013e3181872d3f CrossRefPubMedGoogle Scholar
  11. 11.
    Tran T, Jones CL, Williamson SR, et al. (2016) Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma. Histopathology 68(6):850–857.  https://doi.org/10.1111/his.12840 CrossRefPubMedGoogle Scholar
  12. 12.
    Lawrie CH, Armesto M, Fernandez-Mercado M, et al. (2018) Noncoding RNA expression and targeted next-generation sequencing distinguish tubulocystic renal cell carcinoma (TC-RCC) from other renal neoplasms. J Mol Diagn 20(1):34–45.  https://doi.org/10.1016/j.jmoldx.2017.09.002 CrossRefPubMedGoogle Scholar
  13. 13.
    Al-Hussain TO, Cheng L, Zhang S, Epstein JI (2013) Tubulocystic carcinoma of the kidney with poorly differentiated foci: a series of 3 cases with fluorescence in situ hybridization analysis. Hum Pathol 44(7):1406–1411.  https://doi.org/10.1016/j.humpath.2012.11.015 CrossRefPubMedGoogle Scholar
  14. 14.
    Mego M, Sycova-Mila Z, Rejlekova K, et al. (2008) Sunitinib in the treatment of tubulocystic carcinoma of the kidney. A case report. Ann Oncol 19(9):1655–1656.  https://doi.org/10.1093/annonc/mdn408 CrossRefPubMedGoogle Scholar
  15. 15.
    Hora M, Urge T, Eret V, et al. (2011) Tubulocystic renal carcinoma: a clinical perspective. World J Urol 29(3):349–354.  https://doi.org/10.1007/s00345-010-0614-7 CrossRefPubMedGoogle Scholar
  16. 16.
    Banerjee I, Yadav SS, Tomar V, Yadav S, Talreja S (2016) Tubulocystic renal cell carcinoma: a great imitator. Rev Urol 18(2):118–121.  https://doi.org/10.3909/riu0692 PubMedPubMedCentralCrossRefGoogle Scholar
  17. 17.
    Cornelis F, Helenon O, Correas JM, et al. (2015) Tubulocystic renal cell carcinoma: a new radiological entity. Eur Radiol .  https://doi.org/10.1007/s00330-015-3923-9 CrossRefPubMedGoogle Scholar
  18. 18.
    MacLennan GT, Cheng L (2011) Tubulocystic carcinoma of the kidney. J Urol 185(6):2348–2349.  https://doi.org/10.1016/j.juro.2011.03.043 CrossRefPubMedGoogle Scholar
  19. 19.
    Hindman NM, Bosniak MA, Rosenkrantz AB, Lee-Felker S, Melamed J (2012) Multilocular cystic renal cell carcinoma: comparison of imaging and pathologic findings. AJR Am J Roentgenol 198(1):W20–26.  https://doi.org/10.2214/ajr.11.6762 CrossRefPubMedGoogle Scholar
  20. 20.
    Chu LC, Hruban RH, Horton KM, Fishman EK (2010) Mixed epithelial and stromal tumor of the kidney: radiologic-pathologic correlation. Radiographics 30(6):1541–1551.  https://doi.org/10.1148/rg.306105503 CrossRefPubMedGoogle Scholar
  21. 21.
    Horikawa M, Shinmoto H, Kuroda K, et al. (2012) Mixed epithelial and stromal tumor of the kidney with polypoid component extending into renal pelvis and ureter. Acta Radiologica Short Rep .  https://doi.org/10.1258/arsr.2011.110010 CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Yukiko Honda
    • 1
    Email author
  • Yuko Nakamura
    • 1
  • Keisuke Goto
    • 2
  • Hiroaki Terada
    • 1
  • Kazuhiro Sentani
    • 3
  • Wataru Yasui
    • 3
  • Yohei Sekino
    • 2
    • 3
  • Tetsutaro Hayashi
    • 2
  • Jun Teishima
    • 2
  • Akio Matsubara
    • 2
  • Motonori Akagi
    • 1
  • Tomoyo Fuji
    • 1
  • Yasutaka Baba
    • 1
  • Makoto Iida
    • 1
  • Kazuo Awai
    • 1
  1. 1.Department of Diagnostic RadiologyInstitute of Biomedical and Health Sciences, Hiroshima UniversityHiroshimaJapan
  2. 2.Department of UrologyInstitute of Biomedical and Health Sciences, Hiroshima UniversityHiroshimaJapan
  3. 3.Department of Molecular PathologyInstitute of Biomedical and Health Sciences, Hiroshima UniversityHiroshimaJapan

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